NDUFC1 Inhibitors
NDUFC1 inhibitors belong to a specific class of chemical compounds that target the NADH dehydrogenase (ubiquinone) 1 subunit C1, a crucial component of mitochondrial complex I. Mitochondrial complex I, also known as NADH:ubiquinone oxidoreductase, plays a pivotal role in the electron transport chain, facilitating the transfer of electrons from NADH to ubiquinone. This process is integral to the generation of the proton motive force that drives ATP synthesis and subsequent cellular energy production. NDUFC1, as a subunit within complex I, participates in the catalytic activities that orchestrate the electron transfer reactions.
The inhibitors designed to target NDUFC1 exert their effects by modulating the enzymatic activity of mitochondrial complex I. These compounds are meticulously engineered to interact with specific binding sites on the NDUFC1 subunit, disrupting its normal function in the electron transport chain. By impeding the flow of electrons through complex I, NDUFC1 inhibitors interfere with the generation of the proton gradient, subsequently impacting cellular bioenergetics. The intricate interplay of these inhibitors with NDUFC1 provides a potential avenue for manipulating mitochondrial function, offering insights into cellular processes dependent on oxidative phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is a mitochondrial complex I inhibitor. By inhibiting complex I, where NDUFC1 is a subunit, it prevents the proper function of the electron transport chain, leading to decreased ATP production and subsequent downregulation of NDUFC1 activity. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Piericidin A is also a mitochondrial complex I inhibitor. It specifically targets the ubiquinone binding site, impairing the function of complex I and thus inhibiting the activity of NDUFC1 as part of this complex. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
TTFA is a site-specific inhibitor of mitochondrial complex II. Although it does not directly inhibit NDUFC1, by disrupting complex II it can induce a compensatory increase in complex I activity, which could indirectly affect NDUFC1 function. | ||||||
Dimethyl malonate | 108-59-8 | sc-239778 sc-239778A | 250 ml 1 L | $49.00 $102.00 | 1 | |
Dimethyl malonate is a competitive inhibitor of succinate, substrate for mitochondrial complex II. By inhibiting complex II, it can lead to a buildup of NADH and feedback inhibition of complex I, where NDUFC1 operates. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin is an inhibitor of succinate dehydrogenase, the enzymatic component of mitochondrial complex II. This inhibition can indirectly affect complex I activity and thus NDUFC1 function due to inter-complex signaling within the mitochondria. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $265.00 | 2 | |
Atovaquone is a selective inhibitor of mitochondrial electron transport at complex III. Its inhibition can lead to a compensatory response that affects complex I and potentially the function of NDUFC1. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A is an inhibitor of mitochondrial cytochrome b in complex III. By inhibiting complex III, it affects electron flow and can indirectly inhibit complex I activity, thereby influencing NDUFC1 function. | ||||||