NDUFAB1 Inhibitors
NDUFAB1 inhibitors constitute a diverse group of compounds with distinct mechanisms that either directly target the protein or indirectly modulate its activity through disruption of mitochondrial complexes. Rotenone, a well-known inhibitor, directly binds to the ubiquinone-binding site in mitochondrial complex I, impairing electron transfer and proton pumping. This leads to reduced ATP synthesis, influencing NDUFAB1 activity by disrupting mitochondrial energy production. Piericidin A, another complex I inhibitor, binds to the quinone reduction site, hindering electron transfer and proton pumping. Similar direct inhibitory actions are observed with 2-Thenoyltrifluoroacetone (TTFA) and mefloquine, both impacting complex I function and subsequently influencing NDUFAB1 activity. Additionally, rotenone analog deguelin, resembling rotenone, interferes with complex I, indirectly modulating NDUFAB1.
Lonidamine indirectly affects NDUFAB1 by disrupting complex I function, diminishing proton pumping and ATP synthesis. Amodiaquine and citreoviridin, through direct actions on complex I, also impact NDUFAB1 activity by reducing mitochondrial energy production. Azide, acting on complex IV, indirectly modulates NDUFAB1 by impairing electron transfer and ATP synthesis. Dimercaprol, a chelating agent, indirectly influences NDUFAB1 by mitigating the impact of heavy metals on mitochondrial function. Thioridazine directly inhibits complex I, impacting NDUFAB1 activity by reducing ATP synthesis. Capsaicin, through TRPV1 activation, induces mitochondrial uncoupling, indirectly modulating NDUFAB1 by disrupting energy production. In conclusion, NDUFAB1 inhibitors exhibit diverse mechanisms, ranging from direct interactions with mitochondrial complexes to indirect modulation of energy production. This nuanced understanding offers insights into potential avenues for targeted interventions in mitochondrial function and NDUFAB1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits NDUFAB1 by disrupting mitochondrial complex I. It binds to the ubiquinone-binding site, blocking electron transfer within the respiratory chain. This direct inhibition leads to impaired NADH oxidation, modulating NDUFAB1 activity and hindering ATP synthesis. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Piericidin A inhibits NDUFAB1 by binding to the quinone reduction site of mitochondrial complex I. This direct inhibition disrupts electron transfer, hindering the proton pumping required for ATP synthesis. Piericidin A-induced impairment of complex I function indirectly modulates NDUFAB1 activity, impacting mitochondrial energy production. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
TTFA inhibits NDUFAB1 by binding to the iron-sulfur cluster in mitochondrial complex I. This direct inhibition disrupts electron transfer, leading to impaired proton pumping and reduced ATP synthesis. TTFA-induced modulation of complex I function indirectly influences NDUFAB1 activity, impacting mitochondrial energy production. | ||||||
Lonidamine | 50264-69-2 | sc-203115 sc-203115A | 5 mg 25 mg | $103.00 $357.00 | 7 | |
Lonidamine indirectly inhibits NDUFAB1 by disrupting mitochondrial complex I function. It interferes with complex I-mediated proton pumping, reducing ATP synthesis. This indirect inhibition modulates NDUFAB1 activity by impacting the overall mitochondrial energy production and electron transport chain function. | ||||||
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine inhibits NDUFAB1 by disrupting mitochondrial complex I function. It interferes with electron transfer and proton pumping, leading to reduced ATP synthesis. This direct inhibition modulates NDUFAB1 activity, impacting mitochondrial energy production. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Azide inhibits NDUFAB1 by interfering with mitochondrial complex IV. It binds to the heme cofactors, disrupting electron transfer and impairing ATP synthesis. This indirect inhibition modulates NDUFAB1 activity by impacting the overall mitochondrial electron transport chain function and energy production. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine inhibits NDUFAB1 by disrupting mitochondrial complex I. It interferes with electron transfer and proton pumping, leading to reduced ATP synthesis. This direct inhibition modulates NDUFAB1 activity, impacting mitochondrial energy production. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin indirectly inhibits NDUFAB1 by activating TRPV1 channels. TRPV1 activation triggers mitochondrial uncoupling, reducing proton pumping and ATP synthesis. This indirect modulation impacts NDUFAB1 activity by disrupting the overall mitochondrial energy production and electron transport chain function. | ||||||