NaS-1 Inhibitors
NaS-1 inhibitors belong to a distinct chemical class characterized by their ability to selectively target and modulate the activity of the sodium channel NaS-1. Sodium channels play a crucial role in cellular excitability by facilitating the influx of sodium ions across cell membranes. NaS-1, in particular, is a subtype of sodium channels expressed in various tissues, contributing to the regulation of neuronal excitability and the transmission of electrical signals. The development of NaS-1 inhibitors is rooted in the understanding of the intricate mechanisms governing ion channel function.
Chemically, NaS-1 inhibitors are designed to interact specifically with the NaS-1 channel, altering its conformation and impeding the normal flow of sodium ions. This modulation of sodium channel activity can have profound effects on cellular function, influencing neuronal communication and signal propagation. The structural diversity within the NaS-1 inhibitor class allows for fine-tuning of their interactions with the sodium channel, enabling researchers to explore potential variations in pharmacological profiles. As a result, NaS-1 inhibitors have become pivotal tools in unraveling the intricacies of ion channel physiology, contributing valuable insights into the broader field of neurobiology. Ongoing research aims to further elucidate the specific mechanisms by which NaS-1 inhibitors exert their effects, shedding light on the intricate interplay of molecular events that govern cellular excitability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Sodium ion channel blocker that inhibits epithelial sodium channels (ENaC), which are structurally related to NaS-1. Amiloride binding to these channels leads to reduced sodium ion conductance, thereby indirectly inhibiting NaS-1 activity. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
A local anesthetic and class 1B antiarrhythmic agent that blocks voltage-gated sodium channels. While its primary target is not NaS-1, its action could indirectly result in reduced activity of NaS-1 by decreasing sodium ion permeability. | ||||||
Ranolazine | 95635-55-5 | sc-212769 | 1 g | $107.00 | 3 | |
An chemical that blocks late-phase sodium currents, which may indirectly inhibit NaS-1 activity by stabilizing the membrane potential and reducing the sodium load. | ||||||
A-803467 | 944261-79-4 | sc-201068 sc-201068B sc-201068A | 10 mg 25 mg 50 mg | $87.00 $184.00 $342.00 | 1 | |
A selective blocker of the NaV1.8 sodium channel, which could indirectly affect NaS-1 functionality by altering sodium ion homeostasis. | ||||||