MUS81 Inhibitors
MUS81 inhibitors constitute a diverse group of compounds that either directly target MUS81 or indirectly modulate its activity by affecting key cellular pathways involved in DNA repair and genomic stability. Triapine, a small molecule inhibitor of ribonucleotide reductase, indirectly influences MUS81 by disrupting DNA synthesis and repair processes. Triapine-induced ribonucleotide reduction inhibition leads to altered DNA structures and replication stress, affecting MUS81-mediated resolution of DNA structures. Mirin, an MRE11 inhibitor, indirectly modulates MUS81 activity by interfering with the MRE11-mediated DNA repair pathway. By inhibiting MRE11, Mirin disrupts the processing of DNA structures and impairs the normal function of MUS81 in DNA repair and maintenance.
NSC 19630, an inhibitor of Bloom helicase (BLM), indirectly affects MUS81 by disrupting the BLM-mediated resolution of DNA structures. NSC 19630-induced BLM inhibition leads to altered DNA repair processes, impacting MUS81's role in resolving DNA intermediates and contributing to genomic stability. Camptothecin, a topoisomerase I inhibitor, indirectly affects MUS81 by disrupting DNA topological changes. Camptothecin-induced topoisomerase I inhibition leads to altered DNA structures, affecting MUS81-mediated resolution of DNA intermediates and impairing its role in DNA repair processes. ATR inhibitor (AZD6738), an inhibitor of the ataxia-telangiectasia and Rad3-related (ATR) kinase, indirectly modulates MUS81 by disrupting ATR-mediated DNA damage response pathways. ATR inhibitor-induced ATR inhibition leads to altered DNA repair processes, affecting MUS81-mediated resolution of DNA structures and contributing to genomic stability. A-196, a selective inhibitor of EZH2, indirectly influences MUS81 by targeting the EZH2-mediated epigenetic regulation of gene expression. A-196-induced EZH2 inhibition leads to altered gene expression patterns, affecting pathways involved in DNA repair and modulating MUS81-mediated resolution of DNA structures.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triapine | 200933-27-3 | sc-475303 | 10 mg | $300.00 | ||
Triapine is a small molecule inhibitor of ribonucleotide reductase, indirectly influencing MUS81 activity by disrupting DNA synthesis and repair processes. Triapine-induced ribonucleotide reduction inhibition leads to altered DNA structures and replication stress, affecting MUS81-mediated resolution of DNA structures. | ||||||
NMS-873 | 1418013-75-8 | sc-478803 | 5 mg | $300.00 | ||
NMS-873 is a selective p97 inhibitor that indirectly modulates MUS81 function by disrupting protein homeostasis. As p97 is involved in the turnover of MUS81, NMS-873-induced p97 inhibition results in the accumulation of MUS81, leading to altered DNA repair processes and genomic stability. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a small molecule inhibitor that targets NEDD8-activating enzyme (NAE), indirectly influencing MUS81 by preventing its neddylation. MLN4924-induced inhibition of neddylation disrupts the function of MUS81, affecting the resolution of DNA structures and impairing its role in DNA repair processes. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $141.00 | 4 | |
Mirin is an MRE11 inhibitor that indirectly modulates MUS81 activity by interfering with the MRE11-mediated DNA repair pathway. By inhibiting MRE11, Mirin disrupts the processing of DNA structures and impairs the normal function of MUS81 in DNA repair and maintenance. | ||||||
MIRA-1 | 72835-26-8 | sc-204087 sc-204087A | 10 mg 50 mg | $118.00 $452.00 | 1 | |
MIRA-1 is an inhibitor of Bloom helicase (BLM), indirectly affecting MUS81 by disrupting the BLM-mediated resolution of DNA structures. MIRA-1-induced BLM inhibition leads to altered DNA repair processes, impacting MUS81's role in resolving DNA intermediates and contributing to genomic stability. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that indirectly affects MUS81 by disrupting DNA topological changes. Camptothecin-induced topoisomerase I inhibition leads to altered DNA structures, affecting MUS81-mediated resolution of DNA intermediates and impairing its role in DNA repair processes. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
NU7441 is a DNA-dependent protein kinase (DNA-PK) inhibitor that indirectly modulates MUS81 function by affecting DNA repair processes. NU7441-induced DNA-PK inhibition leads to altered DNA structures and impaired MUS81-mediated resolution of DNA intermediates, contributing to genomic instability. | ||||||
Ceralasertib | 1352226-88-0 | sc-507439 | 10 mg | $573.00 | ||
ATR inhibitor (AZD6738) is an inhibitor of the ataxia-telangiectasia and Rad3-related (ATR) kinase, indirectly modulating MUS81 by disrupting ATR-mediated DNA damage response pathways. ATR inhibitor-induced ATR inhibition leads to altered DNA repair processes, affecting MUS81-mediated resolution of DNA structures and contributing to genomic stability. | ||||||
A-196 | 1982372-88-2 | sc-507414 | 1 mg | $72.00 | ||
A-196 is a selective inhibitor of EZH2, indirectly influencing MUS81 by targeting the EZH2-mediated epigenetic regulation of gene expression. A-196-induced EZH2 inhibition leads to altered gene expression patterns, affecting pathways involved in DNA repair and modulating MUS81-mediated resolution of DNA structures. | ||||||