Date published: 2026-4-26

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mGluR-1b Activators

Santa Cruz Biotechnology now offers a broad range of mGluR-1b inhibitors for use in various applications. mGluR-1b inhibitors are compounds that specifically target the metabotropic glutamate receptor subtype 1b (mGluR1b), a member of the G-protein-coupled receptor family, playing a significant role in synaptic transmission and plasticity. In scientific research, these inhibitors are critical tools for studying the complex mechanisms of neural signaling and the modulation of excitatory neurotransmission in the central nervous system. By selectively inhibiting mGluR1b, researchers can dissect the receptor's specific functions, differentiate its role from other glutamate receptor subtypes, and explore its involvement in various cellular processes, including synaptic plasticity, neurodevelopment, and neuroprotection. This specificity is particularly valuable in neuropharmacological research, where precise manipulation of signaling pathways is essential for understanding the molecular basis of brain function and disease. Additionally, mGluR-1b inhibitors are utilized in studies investigating the receptor's potential contribution to cognitive processes, learning, and memory, providing insights that are fundamental to both basic neuroscience and applied research. The availability of these inhibitors from Santa Cruz Biotechnology ensures that researchers have access to high-quality, reliable reagents, supporting rigorous experimental design and reproducibility. View detailed information on our available mGluR-1b inhibitors by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ro 67-4853

302841-89-0sc-362790
sc-362790A
10 mg
50 mg
$120.00
$490.00
(0)

Ro 67-4853 acts as a selective modulator of the mGluR1b receptor, exhibiting unique allosteric modulation that alters receptor conformation. Its binding affinity is influenced by hydrophobic interactions, which facilitate a distinct pathway for signal transduction. The compound's kinetic profile reveals a slow dissociation rate, allowing for sustained receptor engagement. Additionally, its structural features promote specific interactions with lipid bilayers, enhancing membrane localization and receptor functionality.

(S)-3-Hydroxyphenylglycine

71301-82-1sc-204254
sc-204254A
10 mg
50 mg
$225.00
$930.00
(0)

(S)-3-Hydroxyphenylglycine serves as a selective modulator of the mGluR1b receptor, showcasing unique binding characteristics that promote receptor activation through distinct conformational changes. Its interactions are primarily driven by hydrogen bonding and electrostatic forces, which enhance its affinity for the receptor. The compound's dynamic behavior in solution suggests a propensity for forming stable complexes, influencing downstream signaling pathways and receptor desensitization processes.