Metaxin 3 Inhibitors
Inhibitors targeting the functional activity of Metaxin 3 operate primarily by interfering with the mitochondrial processes that are essential for its role in protein import into the mitochondria. Several compounds achieve this by disrupting the mitochondrial membrane potential, a critical driving force for the translocase machinery of which Metaxin 3 is a component. For instance, agents that impair the electron transport chain at various points, whether at complex I, II, or III, lead to a drop in the electrochemical gradient across the mitochondrial membrane. This decline compromises the ability of the mitochondria to import proteins, consequently diminishing the activity of Metaxin 3. Other inhibitors work by blocking the function of mitochondrial ATP synthase or by directly inhibiting the adenine nucleotide translocator, both of which are integral to maintaining the mitochondrial membrane potential and, thus, the import process requiring Metaxin 3. Additionally, certain inhibitors act as ionophores, altering the balance of ions across the mitochondrial membrane and, by extension, affecting the protein import machinery.
Moreover, some inhibitors have a more nuanced approach, targeting the calcium homeostasis within mitochondria. By either promoting the release of calcium from intracellular stores or preventing its uptake into the mitochondria, these inhibitors can induce changes in mitochondrial dynamics that indirectly impact the functionality of Metaxin 3, given its reliance on the integrity of the organelle for the import of proteins. Furthermore, specific inhibitors can accumulate within mitochondria and interfere with mitochondrial protein synthesis, which can have downstream effects on the protein import processes that Metaxin 3 facilitates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits the activity of calcineurin. Since calcineurin is involved in mitochondrial import through its effect on translocases, its inhibition could decrease the functional activity of Metaxin 3, which is involved in the mitochondrial import process. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits mitochondrial ATP synthase, leading to disruption of mitochondrial membrane potential. This disruption affects proteins dependent on the membrane potential for proper function or import into mitochondria, likely reducing Metaxin 3 activity in mitochondrial protein import. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $418.00 | 10 | |
Bongkrekic acid prevents the opening of the mitochondrial adenine nucleotide translocator pore, which could indirectly inhibit Metaxin 3 by maintaining the mitochondrial membrane potential and impacting the protein import machinery that Metaxin 3 is a part of. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A interferes with the electron transport chain by inhibiting complex III, which could lead to a reduction in mitochondrial membrane potential. As this potential is essential for the import of proteins into mitochondria, Metaxin 3 function could be indirectly inhibited. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits succinate dehydrogenase (complex II) in the electron transport chain, potentially decreasing the mitochondrial membrane potential and indirectly inhibiting Metaxin 3 by affecting mitochondrial protein import processes. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium red is an inhibitor of calcium uptake by mitochondria. By altering mitochondrial calcium homeostasis, it could indirectly influence the mitochondrial protein import machinery, thereby inhibiting Metaxin 3 function. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP uncouples oxidative phosphorylation by dissipating the proton gradient across the mitochondrial membrane, which could reduce the mitochondrial membrane potential, thereby indirectly inhibiting the protein import function of Metaxin 3. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin acts as a potassium ionophore, disrupting the mitochondrial membrane potential. This could indirectly inhibit Metaxin 3 by affecting the electrochemical gradient required for mitochondrial protein import, a process in which Metaxin 3 is implicated. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I, leading to a reduced mitochondrial membrane potential. This could indirectly inhibit Metaxin 3's role in mitochondrial protein import due to its reliance on an intact electrochemical gradient. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline can accumulate in mitochondria and inhibit mitochondrial protein synthesis. This could indirectly lead to a decrease in Metaxin 3 function, as it may alter the import and processing of proteins within the mitochondria where Metaxin 3 is active. | ||||||