megsin Activators
Megsin Activators comprise a range of chemical compounds that directly affect the function of megsin, a serine protease inhibitor predominantly expressed in the kidney, particularly in mesangial cells. These activators, including Angiotensin II, Aldosterone, Dexamethasone, Retinoic acid, Progesterone, Estradiol, LPS, and PMA function through different signaling pathways, primarily the Smad, NF-κB, and JAK-STAT pathways, to enhance megsin functionality. These chemical compounds enhance the functional activity of megsin by influencing signaling pathways that upregulate megsin expression. For instance, Angiotensin II, Aldosterone, Dexamethasone, Retinoic acid, Progesterone, Estradiol, LPS, and PMA enhance megsin expression through the NF-κB pathway.
The increased expression of megsin induced by these chemical compounds can regulate various physiological and pathological processes, particularly those related to renal function. Importantly, these compounds can be used as agents to modulate the activity of megsin in diseases where its expression or activity is deregulated, such as in certain kidney diseases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II can upregulate megsin expression in mesangial cells via activation of the AT1 receptor and subsequent activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||
Aldosterone | 52-39-1 | sc-210774 sc-210774A sc-210774B sc-210774C sc-210774D sc-210774E | 2 mg 5 mg 10 mg 50 mg 100 mg 250 mg | $259.00 $213.00 $317.00 $1550.00 $3074.00 $7637.00 | 1 | |
Aldosterone can increase the expression of megsin in podocytes through the activation of the mineralocorticoid receptor (MR) and subsequent activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone can upregulate megsin expression in mesangial cells via activation of the glucocorticoid receptor (GR) and subsequent activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can increase megsin expression in mesangial cells through the activation of retinoic acid receptor (RAR) and subsequent activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone can upregulate megsin expression in mesangial cells via activation of the progesterone receptor (PR) and subsequent activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol can increase megsin expression in mesangial cells through the activation of estrogen receptor (ER) and subsequent activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS can stimulate megsin expression in mesangial cells through the activation of Toll-like receptor 4 (TLR4) and subsequent activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can increase megsin expression in mesangial cells through activation of protein kinase C (PKC) and downstream activation of the NF-κB pathway, which subsequently enhances the functional activity of megsin. | ||||||