Date published: 2026-4-24

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LTA4H Inhibitors

LTA4H inhibitors belong to a chemical class of compounds that are designed to target and inhibit the enzyme leukotriene A4 hydrolase (LTA4H). LTA4H is a key enzyme involved in the biosynthesis of leukotriene B4 (LTB4), a potent pro-inflammatory lipid mediator. LTB4 is implicated in various inflammatory processes, including immune responses, allergic reactions, and certain diseases. LTA4H inhibitors are specifically designed to bind to the active site of LTA4H and prevent its enzymatic activity, thereby reducing the production of LTB4. These inhibitors are typically small molecules that possess structural features enabling them to interact with the catalytic site of LTA4H. Through their binding, LTA4H inhibitors disrupt the enzymatic pathway and interfere with the conversion of LTA4, an intermediate molecule, into LTB4. By blocking LTB4 production, these inhibitors have the potential to modulate inflammatory responses and help regulate immune cell activation. The three-dimensional structure of the enzyme is considered to guide the synthesis of molecules with suitable chemical properties. By carefully tailoring the chemical structure, researchers aim to achieve high potency, selectivity, and bioavailability of the inhibitors.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Captopril

62571-86-2sc-200566
sc-200566A
1 g
5 g
$49.00
$91.00
21
(1)

Captopril exhibits unique characteristics as an LTA4H inhibitor, showcasing its ability to disrupt leukotriene biosynthesis. Its specific molecular interactions involve competitive binding to the enzyme's active site, which alters the kinetics of substrate conversion. The compound's structural features, including its thiol group, enhance nucleophilicity, promoting effective interactions with electrophilic centers. Additionally, its hydrophilic nature influences solubility and distribution within biological systems, impacting overall reactivity.

SC 57461A

423169-68-0sc-204266
sc-204266A
5 mg
25 mg
$151.00
$577.00
1
(2)

SC 57461A functions as a selective inhibitor of LTA4H, demonstrating distinct molecular interactions that modulate enzyme activity. Its unique structural configuration allows for specific non-covalent interactions with the enzyme, influencing the conformational dynamics and stability of the enzyme-substrate complex. The compound's hydrophobic regions enhance membrane permeability, while its electronic properties facilitate rapid reaction kinetics, contributing to its efficacy in altering leukotriene metabolism.

LTA3 (Leukotriene A3 methyl ester)

83851-38-1sc-200490
sc-200490A
50 µg
1 mg
$167.00
$2000.00
(0)

LTA3 (Leukotriene A3 methyl ester) exhibits unique reactivity as an acid halide, engaging in nucleophilic acyl substitution reactions that highlight its electrophilic nature. Its structural features promote specific interactions with nucleophiles, leading to the formation of stable adducts. The compound's steric hindrance influences reaction rates, while its solubility characteristics enhance its distribution in biological systems, affecting its interaction with various biomolecules.