LPLUNC1 Activators
LPLUNC1 activators encompass a variety of chemical compounds that play distinct roles in modulating inflammation and host defense mechanisms specifically at mucosal surfaces. Lysophosphatidylcholine, through its action on G protein-coupled receptors, initiates a cascade of intracellular signaling that raises calcium levels, which is essential for the enhanced function of LPLUNC1 in defending mucosal barriers. Moreover, metabolites such as Lyso-PAF and Platelet-activating factor (PAF) engage with PAF receptors, leading to an upregulated inflammatory response, a process in which LPLUNC1 has been found to play a critical role. The upregulation is indicative of the compound's ability to enhance LPLUNC1's activity, particularly in the context of pulmonary host defense and inflammation.
Further, signaling molecules like Sphingosine 1-phosphate and ATP, by binding to their respective receptors, set in motion signaling pathways that bolster LPLUNC1's role in mucosal immunity and airway surface liquid regulation. Arachidonic acid, being a precursor to eicosanoids, influences the inflammatory milieu, which in turn can lead to an enhancement of LPLUNC1 activity within lung defense systems. Additionally, compounds like NADPH, Leukotriene B4, Prostaglandin E2, Resolvin D1, and Lipoxin A4, through their individual roles in the modulation of inflammatory responses, can enhance the activity of LPLUNC1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lysophosphatidylcholine (from egg yolk) | 9008-30-4 | sc-473611 sc-473611A sc-473611B sc-473611C | 25 mg 100 mg 500 mg 1 g | $87.00 $235.00 $607.00 $1102.00 | 1 | |
Lysophosphatidylcholine acts on G protein-coupled receptors, leading to an increase in intracellular calcium, which can enhance LPLUNC1 function in host defense and inflammation regulation. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
PAF triggers PAF receptor signaling, which can lead to enhanced LPLUNC1 activity due to its role in modulating inflammation and immune responses. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its receptors, which can promote pathways that enhance LPLUNC1 activity in pulmonary defense mechanisms. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
As a precursor of eicosanoids, it can modulate inflammatory processes and enhance the activity of LPLUNC1 involved in lung defense mechanisms. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH is essential for ROS generation, which can lead to an enhanced inflammatory response and potentially upregulate LPLUNC1 activity. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
LTB4 interacts with its receptors to induce proinflammatory signaling, which can enhance LPLUNC1 function in airway inflammation and host defense. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 interacts with its EP receptors, potentially leading to signaling events that enhance the functional activity of LPLUNC1 in mucosal protection. | ||||||
Resolvin D1 | 872993-05-0 | sc-204877 sc-204877A | 10 µg 25 µg | $262.00 $614.00 | 1 | |
Resolvin D1 binds to GPCRs and can lead to anti-inflammatory signaling that enhances LPLUNC1's role in resolving inflammation. | ||||||
Lipoxin A4 | 89663-86-5 | sc-201060 sc-201060A sc-201060B sc-201060C | 25 µg 50 µg 100 µg 250 µg | $349.00 $495.00 $941.00 $2066.00 | 2 | |
Lipoxin A4 interacts with its receptors to initiate anti-inflammatory actions that can enhance the activity of LPLUNC1 in the resolution phase of inflammation. | ||||||