LPAAT-θ Activators
Lysophosphatidic acid acyltransferase-theta (LPAAT-θ) activators belong to a specific chemical class that plays a pivotal role in cellular lipid metabolism. LPAAT-θ is an enzyme involved in the final step of triglyceride synthesis, where it catalyzes the acylation of lysophosphatidic acid (LPA) to generate phosphatidic acid (PA). This process is essential for the production of glycerophospholipids, key constituents of cellular membranes, and triglycerides, crucial for energy storage. LPAAT-θ activators modulate the enzymatic activity of LPAAT-θ, thereby influencing the rate of triglyceride biosynthesis and cellular lipid homeostasis.
The chemical structure of LPAAT-θ activators is characterized by specific functional groups and molecular features that enable interaction with the LPAAT-θ enzyme. These activators may function through allosteric regulation or direct binding to the enzyme, leading to conformational changes that enhance its catalytic activity. Understanding the structure-activity relationship of these compounds is crucial for elucidating their mode of action and potential applications in lipid-related cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPAR agonist that potentially activates LPAAT-θ by modulating peroxisome proliferator-activated receptors involved in lipid metabolism. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
mTOR activator, potentially activating the mammalian target of rapamycin pathway, which may indirectly activate LPAAT-θ involved in lipid synthesis. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
AMPK activator, potentially activating LPAAT-θ through AMP-activated protein kinase-mediated pathways related to cellular energy and lipid metabolism. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
LXR agonist, potentially activating LPAAT-θ through activation of liver X receptors involved in lipid metabolism and cholesterol homeostasis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
cAMP elevating agent and adenylate cyclase activator, potentially activating LPAAT-θ through cAMP-mediated signaling pathways related to lipid metabolism. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator, activating LPAAT-θ through protein kinase C-mediated signaling pathways involved in cellular processes, including lipid metabolism. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
Thyroid hormone activating metabolism and potentially impacting LPAAT-θ through pathways related to thyroid hormone activation. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
S1P receptor modulator, may activate LPAAT-θ through signaling pathways associated with sphingosine-1-phosphate and its role in lipid metabolism. | ||||||