LAPTM4B Activators
LAPTM4B Activators encompass a diverse array of chemical compounds that influence cellular signaling pathways and lysosomal functions, thereby enhancing the activity of LAPTM4B. Compounds such as Phosphatidylinositol 3-phosphate and Lysophosphatidic acid indirectly augment LAPTM4B's role in endosomal sorting and trafficking by modifying the lipid signaling environment with which LAPTM4Binteracts. Phosphatidylinositol 3-phosphate, a pivotal signaling lipid, associates with LAPTM4B in PI3P-enriched domains of endosomal membranes to facilitate trafficking, while Lysophosphatidic acid activates G protein-coupled receptors to bolster the PI3K/Akt pathway, promoting cellular survival signals that are conducive to LAPTM4B's functional roles. U18666A and Fumonisin B1 manipulate cholesterol transport and sphingolipid metabolism, respectively, leading to cellular conditions that could enhance LAPTM4B's regulation of lipid distribution and storage within lysosomes. Furthermore, agents like EGF and Nicotinic acid modulate growth factor pathways and NAD+-dependent lysosomal functions, thereby indirectly contributing to the optimization of LAPTM4B's contribution to cellular proliferation and lysosomal enzymatic processes.
Compounds such as Chloroquine and Bafilomycin A1, by increasing lysosomal pH, impact the protein trafficking and turnover, indirectly potentiating LAPTM4B's involvement in these processes. Rapamycin, an mTOR inhibitor, enhances autophagic activity, potentially amplifying LAPTM4B's role in autophagosome-lysosome fusion. Forskolin, through cAMP elevation and subsequent PKA activation, may alter lysosomal biogenesis and function, implicating a supportive role for LAPTM4B in these pathways. Retinoic acid, influencing gene expression related to cellular differentiation, may elevate LAPTM4B's functionality in growth and proliferation contexts. Lastly, Sphingosine-1-phosphate, by modulating survival signaling pathways, could indirectly elevate LAPTM4B's activities in maintaining lysosomal integrity and dynamics, underlining the intricate web of signaling pathways that these activators manipulate to enhance the functional repertoire of LAPTM4B.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Lysophosphatidic acid (LPA) is a bioactive lipid that activates G protein-coupled receptors, leading to the activation of the PI3K/Akt pathway. This activation can increase the functional activity of LAPTM4B by promoting its role in cellular growth and survival signaling. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A is a cholesterol transport inhibitor that causes the accumulation of cholesterol in late endosomes and lysosomes. This can enhance LAPTM4B function related to the regulation of intracellular cholesterol distribution and lysosomal lipid storage. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $117.00 $469.00 | 18 | |
Fumonisin B1 inhibits ceramide synthase, leading to alterations in sphingolipid metabolism. Changes in membrane lipid composition can influence the localization and function of LAPTM4B in endosomal/lysosomal trafficking. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic acid, a form of vitamin B3, can enhance lysosomal function by acting as a precursor for NAD+, which is essential for the activity of sirtuins and other NAD+-dependent enzymes that LAPTM4B may interact with or influence in lysosomal function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises endosomal and lysosomal pH, which can affect the trafficking and turnover of membrane proteins, potentially enhancing the function of LAPTM4B in these compartments. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in cell growth and autophagy. Inhibition of mTOR can increase autophagic flux, potentially enhancing the role of LAPTM4B in autophagic processes and lysosomal function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is an inhibitor of the vacuolar-type H+-ATPase (V-ATPase), leading to increased lysosomal pH. This may indirectly enhance LAPTM4B's role in lysosomal function and autophagy. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can activate PKA. Activation of PKA has the potential to influence lysosomal function and biogenesis, indirectly enhancing the activity of LAPTM4B. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate the expression of genes involved in cellular differentiation and proliferation. It may increase the functional activity of LAPTM4B by affecting gene expression patterns in which LAPTM4B plays a regulatory role. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate is a signaling sphingolipid that can influence cellular survival and proliferation pathways. By modulating these pathways, S1P may indirectly enhance the function of LAPTM4B, particularly in the regulation of lysosomal dynamics and function. | ||||||