KRTDAP can play a role in the functional upregulation of this protein through various biochemical and cellular pathways. Retinoic Acid, for instance, through its interaction with retinoid receptors, has a role in the cellular differentiation of keratinocytes which can result in the activation of KRTDAP. Similarly, Vitamin D3, and its active metabolite 1,25-Dihydroxyvitamin D3, can bind to the vitamin D receptor, enhancing keratinocyte differentiation, a process that is known to involve KRTDAP. Activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) is also a significant event that contributes to the differentiation of cells and thus can activate KRTDAP. Forskolin raises cAMP levels which, through PKA-dependent signaling pathways, can lead to the activation of KRTDAP in line with cellular differentiation processes.
The modulation of intracellular calcium levels is another pathway that can lead to the activation of KRTDAP. Ionomycin and Calcimycin, both calcium ionophores, increase intracellular calcium, which is a crucial second messenger in several signaling pathways that oversee the functions including the activation of KRTDAP in keratinocytes. Zinc Pyrithione can activate metallothioneins and thereby influence keratinocyte homeostasis and differentiation that encompasses the activation of KRTDAP. Methotrexate can induce the activation of KRTDAP through the accumulation of adenosine and subsequent activation of adenosine receptor signaling, which is crucial in keratinocyte differentiation. Sphingosine-1-phosphate operates through its receptors to initiate signaling pathways that can activate KRTDAP in the context of keratinocyte function. Furthermore, Lithium Chloride's inhibition of GSK-3β can lead to the activation of Wnt signaling, a pathway intricately linked to the regulation of keratinocyte differentiation and hence the activation of KRTDAP. Lastly, Epidermal Growth Factor (EGF) can engage its receptor to trigger downstream signaling cascades that are involved in cellular proliferation and differentiation, processes that are fundamental to the activation of KRTDAP.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates retinoid receptors, which can lead to the activation of KRTDAP by enhancing differentiation in keratinocytes. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, through its active metabolite calcitriol, binds to the vitamin D receptor, promoting keratinocyte differentiation and potentially leading to the activation of KRTDAP. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in cell differentiation processes that could include the activation of KRTDAP in keratinocytes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially leading to the activation of KRTDAP through calcium-dependent signaling pathways in keratinocytes. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This active form of Vitamin D3 binds the vitamin D receptor, which may activate KRTDAP by promoting keratinocyte differentiation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione can activate metallothioneins, which might affect keratinocyte homeostasis and differentiation, thereby potentially activating KRTDAP. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcimycin is another calcium ionophore that can raise intracellular calcium levels, similar to Ionomycin, potentially activating KRTDAP through calcium-mediated signaling pathways. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate, an antifolate drug, can lead to the accumulation of adenosine, which may activate KRTDAP through adenosine receptors signaling pathways involved in keratinocyte differentiation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule binds to its receptors, which could activate signaling pathways leading to the activation of KRTDAP in keratinocytes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β and can lead to the activation of Wnt signaling, which is involved in the regulation of keratinocyte differentiation and possibly the activation of KRTDAP. | ||||||