KLHL23 Inhibitors

KLHL23, or Kelch-Like Family Member 23, belongs to a broad group of proteins characterized by the presence of kelch motifs – sequences vital for mediating protein-protein interactions. This protein family is integral to a variety of cellular functions, ranging from cytoskeletal organization to cellular signaling. KLHL23, in particular, participates in ubiquitination processes, serving as a substrate adaptor for Cullin-3 based E3 ligases, which play a pivotal role in protein degradation and cell cycle control. The Kelch-like family, to which KLHL23 belongs, is integral to various cellular functions, with many of its members playing roles in ubiquitination processes and protein degradation. KLHL23's relationship with the KEAP1/NRF2 pathway provides a perspective on its indirect regulatory mechanisms. The above-mentioned inhibitors predominantly target the KEAP1/NRF2 pathway, emphasizing the interconnectivity within cellular networks. For instance, ML385 and Brusatol target NRF2 directly, modulating its activity, which could, in turn, influence pathways or processes associated with KLHL23. Additionally, natural compounds like wogonin, luteolin, and apigenin act on NRF2's stability and transcriptional activity, underscoring the diverse avenues through which KLHL23 can be influenced indirectly. The elaborate nature of these connections exemplifies the importance of understanding the broader cellular context when examining KLHL23's function and regulation.