KIF26A Activators
KIF26A Activators are chemical compounds that influence microtubule dynamics, energy supply, and cellular transport demands, which in turn can enhance the functional activity of KIF26A. KIF26A, a kinesin family motor protein, relies on the integrity and dynamics of microtubules to mediate its role in intracellular transport. Compounds such as Paclitaxel, Taxol, and Epothilone B stabilize microtubules, ensuring that KIF26A has a consistent and stable platform on which to "walk" and carry out its transport functions. In contrast, agents like Nocodazole, Colchicine, Vinblastine, and Indanocine disrupt microtubule polymerization, but at low concentrations, these compounds can create a dynamic microtubule network that may actually stimulate KIF26A's motor activity by providing more binding sites or by inducing compensatory cellular responses that require KIF26A-mediated transport.
Additionally, the availability of energy in the form of ATP is critical for KIF26A's motor function. Compounds like 5-Iodotubercidin increase intracellular ATP levels, enhancing KIF26A's ATPase activity, which is necessary for its motor function. Similarly, Adenylyl imidodiphosphate,a non-hydrolyzable ATP analog, can bind to KIF26A and enhance its microtubule association, which can indirectly increase cargo transport efficiency. Beyond influencing microtubule dynamics and energy supply, some compounds affect cellular transport through modulation of other kinesins or cell cycle regulators. For instance, Alsterpaullone's inhibition of cyclin-dependent kinases can alter the cell cycle, increasing demand for KIF26A's transport services. S-Trityl-L-cysteine and Monastrol, by inhibiting other kinesin proteins, may shift the cellular dependency onto KIF26A, hence upregulating its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, which can enhance the activity of KIF26A as this kinesin family member requires intact microtubules to function properly. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization; at low concentrations, it can create a dynamic microtubule environment that may stimulate KIF26A activity by increasing the need for microtubule-based transport. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization; subtle alterations in microtubule dynamics induced by low doses of colchicine can enhance the activity of KIF26A by modulating its interaction with the cytoskeleton. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule assembly; at sub-nanomolar concentrations, it can modulate microtubule dynamics, which may enhance KIF26A's ability to bind to microtubules and perform its motor function. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor that could enhance the activity of KIF26A by affecting the cell cycle and thus modulating the demand for intracellular transport during different phases. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
5-Iodotubercidin is an adenosine kinase inhibitor that could increase the availability of ATP, potentially enhancing the ATPase activity of KIF26A and thus its motor function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Adenylyl imidodiphosphate is a non-hydrolyzable analog of ATP that may bind to KIF26A and enhance its binding to microtubules without promoting dissociation, thus enhancing its motor activity. | ||||||
Indan-2-carboxylic acid | 25177-85-9 | sc-252902 sc-252902A | 250 mg 1 g | $88.00 $250.00 | ||
Indanocine is a microtubule-destabilizing agent; at specific concentrations, it could enhance KIF26A activity by increasing the need for cellular transport mechanisms that rely on the motor protein's function. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B is a microtubule stabilizer that could enhance KIF26A activity by providing a robust framework for its motor domain to effectively transport cellular cargo. | ||||||