KID Activators
KIF22, commonly known as kinesin-like DNA-binding protein (Kid), is a molecular motor protein belonging to the kinesin family that plays a crucial role in the regulation of mitosis. The complex movements and functions of kinesins, including KIF22, are integral to cellular processes such as spindle formation, chromosome segregation, and the maintenance of chromosomal stability during cell division. These proteins convert chemical energy, provided by ATP hydrolysis, into mechanical work that powers the transportation of various cellular cargoes along the microtubule network within the cell. The precise modulation of KIF22 activity is therefore essential for ensuring the proper execution of mitotic events.
KID activators are chemical agents that interact with KIF22 to modulate its activity. As a class, these molecules are characterized by their ability to bind to KIF22 and influence its function in a non-native manner. The interaction between KID activators and KIF22 may affect the protein's ATPase activity, which is central to its motor function. By altering the dynamics of ATP hydrolysis, these activators can impact the rate at which KIF22 moves along microtubules, or the force it exerts on cellular structures during mitosis. The exact mechanisms through which KID activators exert their effects are subject to ongoing research, but they could involve changes in the protein's conformation, its affinity for ATP or microtubules, or its interaction with other regulatory proteins. These molecules are a focal point for investigations into the fundamental understanding of kinesin motor proteins and their roles in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpenoid with the ability to directly stimulate adenylyl cyclase, thereby increasing cyclic AMP (cAMP) levels within cells. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate various proteins, potentially including KID (KIF22). Phosphorylation by PKA can enhance the motor activity of KIF22 by altering its conformation or interaction with other proteins or microtubules. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and is known to activate protein kinase C (PKC). PKC can phosphorylate a broad range of cellular targets, which may include KID (KIF22). Activation of PKC and subsequent phosphorylation can enhance KID's binding to microtubules or alter its motor function. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to its receptor, initiating a cascade that activates phosphoinositide 3-kinase (PI3K) and downstream AKT. AKT can phosphorylate multiple substrates, potentially affecting KID's motor activity or its interaction with ATP or microtubules. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a toxin that inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins. This can enhance KID's activity if its function is regulated by dephosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases, particularly PP1 and PP2A, similar to Calyculin A, leading to increased phosphorylation of proteins within the cell, which could include KID, thereby enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium/calmodulin-dependent protein kinases (CaMKs). These kinases can phosphorylate a range of targets, potentially influencing KID's activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to altered phosphorylation states of various substrates that might interact with or regulate KID, thereby enhancing its function. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that can permeate cell membranes and activate PKA intracellularly. PKA activation can lead to phosphorylation events that enhance KID's motor functions. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation. While generally an inhibitor, it can indirectly enhance KID's function by preventing deactivation or sequestration, effectively increasing the available KID for cellular processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can potentially enhance KID's activity by increasing the stability of microtubules, allowing for more efficient motor function. | ||||||