KIAA1530 Inhibitors

The class of chemicals known as KIAA1530 Inhibitors mainly encompasses compounds that target various aspects of DNA repair or DNA damage response pathways. Given UVSSA's role in transcription-coupled nucleotide excision repair (TC-NER), the compounds listed can indirectly influence its functional contributions to DNA repair. These inhibitors often target key enzymes involved in DNA repair processes, such as topoisomerases, DNA-PK, ATM, and ATR kinases, PARP, and others.

By inhibiting these enzymes, the chemicals disrupt the proper functioning of DNA repair pathways, thereby indirectly affecting the proteins, including UVSSA, involved in these pathways. For instance, topoisomerase inhibitors like camptothecin and etoposide induce DNA breaks and by inhibiting the repair of these breaks, indirectly modulate the functional roles of proteins implicated in DNA repair. Similarly, PARP inhibitors such as olaparib prevent the repair of single-strand breaks, which can escalate to double-strand breaks if not repaired. As the cell's repair machinery attempts to address these lesions, proteins like UVSSA are indirectly influenced.