IL1R2 Inhibitors
IL-1RII inhibitors encompass a range of compounds that modulate the activity of the IL-1 receptor type II either through direct binding or indirect modulation of related pathways. These compounds affect the function of IL-1RII by altering the availability or activity of its ligands, mainly IL-1β, or by interfering with downstream signaling processes. The compounds listed include both small molecules and larger biomolecules that have been identified through their ability to interfere with the IL-1 signaling cascade at various points, from ligand maturation to receptor-ligand interaction and downstream effectors.
The chemical class of IL-1RII inhibitors is not restricted to a single type of molecule but includes diverse structures ranging from proteins to organic compounds. The action of these inhibitors is centered on the disruption of the normal biological activity of IL-1RII, with some acting to the binding of IL-1 to the receptor, while others act upstream to reduce the synthesis or release of IL-1 itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Diethyl sulfoxide (DMSO) is a solvent known to affect various biological processes; it may alter IL-1RII protein conformation or membrane interactions, potentially modifying its function. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $45.00 $60.00 $115.00 $170.00 $520.00 | 36 | |
Glyburide is a sulfonylurea compound that has been shown to inhibit the release of IL-1β from inflammasomes, which could decrease IL-1 signaling through IL-1RII by reducing the amount of IL-1β available to bind. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine disrupts microtubule polymerization and can inhibit the release of IL-1β, indirectly impacting IL-1RII signaling by reducing extracellular levels of IL-1β. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is a sesquiterpene lactone that can inhibit the NF-κB pathway and the NLRP3 inflammasome, leading to reduced production and release of IL-1β, thus indirectly affecting IL-1RII function. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Andrographolide is a diterpenoid compound known to inhibit NF-κB activation and may reduce the synthesis of IL-1β, thereby indirectly impacting IL-1RII signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 is an inhibitor of the NF-κB pathway, which can decrease the transcription of pro-inflammatory cytokines including IL-1β, indirectly affecting IL-1RII activity. | ||||||