Date published: 2025-10-25

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Ichthyin Inhibitors

Ichthyin Inhibitors form a specialized chemical class of compounds that have garnered scientific interest for their potential to selectively modulate the activity of the ichthyin protein, also known as NIPAL4. Ichthyin is a protein associated with skin disorders known as ichthyoses, a group of rare genetic conditions characterized by impaired skin barrier function and abnormal scaling of the skin. The chemical class of Ichthyin Inhibitors is designed to interact with specific regions or binding sites within the ichthyin protein. By engaging with ichthyin, these inhibitors aim to modulate its functional activity, which might include regulating cellular processes relevant to skin barrier function, lipid metabolism, or epidermal differentiation. Inhibiting ichthyin's activity could potentially offer insights into the underlying molecular mechanisms contributing to the pathogenesis of ichthyosis-related skin disorders, thus contributing to our understanding of skin biology and dermatological health.

However, it is essential to underscore that the field of Ichthyin Inhibitors is continuously evolving, and comprehensive investigations are necessary to fully elucidate the precise mechanisms of action and potential selectivity of these compounds for ichthyin. As researchers delve deeper into the functional implications of ichthyin inhibition, the ongoing exploration of Ichthyin Inhibitors holds promise in advancing our understanding of this protein's biological significance and could lead to novel discoveries and future research avenues in skin biology and related fields.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Found in vitamin A and can modulate gene expression and cellular differentiation.

Tazarotene

118292-40-3sc-220193
10 mg
$103.00
(0)

Tazarotene is a prodrug for tazarotenic acid with selective affinity for RARβ and RARγ

Bexarotene

153559-49-0sc-217753
sc-217753A
10 mg
100 mg
$54.00
$245.00
6
(1)

Bexarotene is a selective agonist of retinoid X receptors

Acitretin

55079-83-9sc-210754
25 mg
$148.00
1
(1)

Acitretin is a synthetic retinoid - the major metabolite of etretinate

Vitamin A

68-26-8sc-280187
sc-280187A
1 g
10 g
$377.00
$2602.00
(2)

A form of vitamin A with potential biological activities.

Adapalene

106685-40-9sc-203803
sc-203803A
10 mg
50 mg
$65.00
$325.00
2
(0)

Adapalene is a retinoic acid analog and apoptosis inducer

13-cis-Retinoic acid

4759-48-2sc-205568
sc-205568A
100 mg
250 mg
$74.00
$118.00
8
(1)

13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$92.00
$209.00
33
(5)

An immunosuppressive and anti-inflammatory agent.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$62.00
$90.00
$299.00
$475.00
$1015.00
$2099.00
69
(5)

Cyclosporin A is a fungal metabolite calcineurin and mitochondrial permeability transition pore opening inhibitor.

Calcipotriol

112965-21-6sc-203537
sc-203537A
10 mg
50 mg
$199.00
$816.00
4
(1)

Calcipotriol is vitamin D3 analog