HSV-2 ICP8 Major DNA binding protein Inhibitors
The class of compounds referred to as HSV-2 ICP8 Major DNA binding protein Inhibitors belongs to a category of chemical agents that have demonstrated an ability to interact with and modulate the activity of the HSV-2 ICP8 Major DNA binding protein. This specific protein, encoded by the herpes simplex virus type 2 (HSV-2), plays a pivotal role in the viral DNA replication process. The inhibitors within this chemical class are designed to selectively target the binding interaction between the HSV-2 ICP8 protein and its associated DNA substrates.
These inhibitors typically exhibit a high affinity for the DNA binding domain of the HSV-2 ICP8 protein, effectively disrupting its ability to engage with viral DNA strands. This interference with the DNA binding process subsequently hinders the proper functioning of the DNA replication machinery, which is crucial for the virus's life cycle. The chemical structures and properties of these inhibitors are carefully designed to ensure a specific and effective interaction with the target protein, thereby offering tools for further research into the viral replication mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $150.00 $940.00 | 2 | |
Acyclovir is a nucleoside analog that gets incorporated into growing viral DNA chains, causing chain termination and inhibiting DNA synthesis by acting as a competitive inhibitor of the viral DNA polymerase. | ||||||
Penciclovir | 39809-25-1 | sc-203183 | 100 mg | $260.00 | ||
Similar to acyclovir, penciclovir is a nucleoside analog that interferes with viral DNA synthesis by inhibiting the viral DNA polymerase, leading to premature chain termination. | ||||||
Famciclovir | 104227-87-4 | sc-211498 | 100 mg | $123.00 | ||
Famciclovir is a prodrug that gets converted to penciclovir in the body. Like penciclovir, it inhibits viral DNA synthesis by interfering with the action of the viral DNA polymerase. | ||||||
Ganciclovir | 82410-32-0 | sc-203963 sc-203963A | 50 mg 250 mg | $233.00 $421.00 | 1 | |
Ganciclovir is a nucleoside analog that inhibits viral DNA polymerase, causing chain termination and preventing further viral DNA elongation. It is often used in cytomegalovirus infections. | ||||||
Cidofovir | 113852-37-2 | sc-482141 | 50 mg | $135.00 | ||
Cidofovir is a nucleotide analog that competitively inhibits viral DNA polymerase and is phosphorylated within cells. The active form of cidofovir inhibits DNA synthesis by viral polymerase. | ||||||
Foscarnet sodium | 63585-09-1 | sc-205330 sc-205330A | 1 g 5 g | $190.00 $676.00 | ||
Foscarnet is a pyrophosphate analog that directly inhibits viral DNA polymerase by binding to the enzyme's active site and disrupting the cleavage of pyrophosphate during DNA synthesis. | ||||||