HSPA4L Activators
HSPA4L activators belong to a chemical class designed to interact with the heat shock protein A4 like (HSPA4L), which is part of the larger HSP70 family of proteins. These molecules are characterized by their ability to modulate the function of HSPA4L, which plays a role in the cellular response to stress. The HSP70 family, to which HSPA4L is related, are conserved across various species and are known for their role in protein folding, assisting in the refolding of misfolded proteins, and in the protection of cells under conditions that can cause proteins to denature. Activators of HSPA4L, therefore, by influencing the activity of this particular protein, can have a significant impact on the cellular mechanisms involved in the maintenance of protein homeostasis, known as proteostasis.
The precise molecular structure of HSPA4L activators varies, but these compounds typically share an affinity for binding to certain domains within the HSPA4L protein, thereby modulating its activity. The interaction between the activators and HSPA4L influences its ATPase activity, which is crucial for the protein's function in the ATP-dependent chaperoning cycle. By binding to HSPA4L, activators may alter the conformational dynamics of the protein, potentially enhancing its ability to bind and stabilize unfolded or misfolded proteins. This modulation of HSPA4L activity by its activators is a subject of interest within the broader field of study surrounding the regulation of heat shock proteins and their role in maintaining cellular homeostasis under stress conditions. Understanding how HSPA4L activators function at a biochemical level is critical for comprehending how cells manage proteostasis and respond to various types of cellular stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and inhibits its activity. Since Hsp90 is known to stabilize several client proteins, its inhibition can lead to the upregulation of heat shock proteins such as HSPA4L as a compensatory response to counterbalance misfolded proteins. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG, a derivative of Geldanamycin, also targets Hsp90, leading to an increase in other heat shock proteins including HSPA4L. This occurs as the cellular machinery attempts to maintain protein homeostasis when Hsp90-dependent folding is compromised. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol induces heat shock response by increasing the expression of heat shock proteins like HSPA4L. It does so by triggering the transcription factor heat shock factor 1 (HSF1), which enhances the transcription of heat shock proteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that causes an accumulation of ubiquitinated proteins, inducing a stress response that includes upregulation of heat shock proteins such as HSPA4L to assist in protein refolding and degradation pathways. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal is a selective inhibitor of phosphatases that dephosphorylate eukaryotic translation initiation factor 2 alpha (eIF2α). The inhibition of this dephosphorylation leads to an enhanced stress response and increased expression of HSPA4L. | ||||||
Zinc sulfate solution | 7733-02-0 | sc-251451 | 250 ml | $112.00 | ||
Zinc sulfate can induce metal stress and a subsequent increase in heat shock protein expression, including HSPA4L, to protect cells against the toxic effects of heavy metals by improving protein folding and reducing aggregation. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin blocks N-linked glycosylation, leading to endoplasmic reticulum stress and the unfolded protein response (UPR), which in turn upregulates heat shock proteins including HSPA4L as part of the adaptive stress response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can induce the expression of heat shock proteins such as HSPA4L by activating HSF1, as well as by mitigating oxidative stress, thus enhancing the cellular protective response. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A disrupts cytoskeletal organization, leading to heat shock response activation and subsequent upregulation of heat shock proteins like HSPA4L to counteract the stress-induced misfolding of proteins. | ||||||