HPV16 E5 Inhibitors
Chemical inhibitors of HPV16 E5 employ diverse mechanisms to disrupt the functional activities of this protein within the cellular environment. Auranofin targets the redox regulation on which HPV16 E5 relies by inhibiting thioredoxin reductase, leading to an oxidative environment that is detrimental to the protein's stability. Similarly, Bepridil disrupts the calcium homeostasis essential for HPV16 E5's modulation of cellular pathways, effectively altering the intracellular milieu and inhibiting the protein's ability to manipulate these pathways. Bortezomib, a proteasome inhibitor, impedes the degradation of proteins within the cell, potentially causing an accumulation of misfolded HPV16 E5 proteins and preventing their proper function. Genistein exerts its inhibitory effect by blocking tyrosine kinases, thus reducing the growth factor signaling that HPV16 E5 enhances for its benefits.
Continuing with this theme of cellular interference, Itraconazole impacts the Hedgehog signaling pathway, which HPV16 E5 upregulates to foster cell proliferation and survival, thereby indirectly inhibiting the protein's function. Ketoconazole, through its action on sterol synthesis, alters the lipid composition of cellular membranes where HPV16 E5 is active, consequently affecting the protein's activities. Lonafarnib prevents the farnesylation of proteins, a modification that is requisite for the function of proteins involved in signaling pathways used by HPV16 E5, thereby disrupting these critical pathways. PD168393 specifically inhibits the EGFR tyrosine kinase and hence can thwart the downstream signaling that HPV16 E5 exploits. Rapamycin, by inhibiting mTOR, affects the PI3K/AKT/mTOR pathway, which is crucial for HPV16 E5's role in cellular survival. Lastly, Silibinin acts on transcription factors; it inhibits STAT3 and NF-kB, which is activated by HPV16 E5 to facilitate an environment favorable for its operations. Each of these chemical inhibitors, through their unique modes of action, can interfere with the functionality of HPV16 E5 within the cell.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin inhibits the activity of thioredoxin reductase (TrxR). Since HPV16 E5 protein has been shown to rely on redox regulation and may interact with TrxR to maintain a reduced environment for its function, the inhibition of TrxR by Auranofin can lead to an oxidative environment that is detrimental to the stability and function of HPV16 E5. | ||||||
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil is known to disrupt calcium homeostasis by blocking calcium channels. HPV16 E5 has been implicated in modulating calcium signaling pathways to favor viral replication and persistence. By altering calcium homeostasis in the cell, Bepridil can inhibit the HPV16 E5's ability to manipulate this pathway, thereby functionally inhibiting the protein. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor. The ubiquitin-proteasome system is crucial for the turnover of many cellular proteins, including viral oncoproteins. By inhibiting the proteasome, Bortezomib can lead to the accumulation of misfolded or aggregated proteins, which may include HPV16 E5, thus inhibiting its proper function within the cell. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. HPV16 E5 has been shown to augment growth factor signaling, partially through the activation of certain tyrosine kinases. By inhibiting these kinases, Genistein can reduce the downstream signaling necessary for HPV16 E5 to exert its effects, thereby functionally inhibiting the protein. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole has been shown to inhibit Hedgehog signaling. HPV16 E5 can upregulate components of this pathway, which are essential for its mediated effects on cell proliferation and survival. By targeting Hedgehog signaling, Itraconazole can inhibit the pathway's activity, which is necessary for HPV16 E5's function, thus indirectly inhibiting the protein. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole disrupts sterol synthesis by inhibiting the enzyme cytochrome P450 14α-demethylase. HPV16 E5's function is connected to membrane dynamics and lipid rafts, which are influenced by sterol composition. By inhibiting sterol synthesis, Ketoconazole can alter the membrane properties that are essential for HPV16 E5's activity, hence functionally inhibiting the protein. | ||||||
Lonafarnib | 193275-84-2 | sc-482730 sc-482730A | 5 mg 10 mg | $173.00 $234.00 | ||
Lonafarnib is a farnesyltransferase inhibitor. It prevents the farnesylation of proteins, a post-translational modification required for the proper function of many proteins, including those involved in signal transduction pathways exploited by HPV16 E5. By inhibiting this modification, Lonafarnib can disrupt signaling pathways that are essential for the functional activity of HPV16 E5, leading to its inhibition. | ||||||
PD 168393 | 194423-15-9 | sc-222138 | 1 mg | $162.00 | 4 | |
PD168393 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. By inhibiting EGFR, PD168393 can disrupt the downstream signaling that HPV16 E5 may utilize to promote survival and proliferation of the infected cells, thereby inhibiting the functional effects of HPV16 E5. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, which is part of the PI3K/AKT/mTOR pathway, a pathway that can be affected by HPV16 E5 to promote cellular survival and viral replication. By inhibiting mTOR, Rapamycin can disrupt the activity of this pathway, which is necessary for HPV16 E5's functionality, thus resulting in the inhibition of the protein. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silibinin is an inhibitor of STAT3 and NF-kB. HPV16 E5 can activate these transcription factors to promote an environment conducive to viral replication and persistence. By inhibiting STAT3 and NF-kB, Silibinin can disrupt the signaling cascades that HPV16 E5 relies on, leading to its functional inhibition. | ||||||