HOOK3 Activators

Hook Microtubule Tethering Protein 3 (HOOK3) is a protein encoded by the HOOK3 gene in humans. As part of the Hook family of proteins, which also includes HOOK1 and HOOK2, HOOK3 interacts with microtubules, the structural components of the cell that help maintain its shape and play crucial roles in cell division, intracellular transport, and motility.HOOK3 is involved in tethering and transportation of intracellular organelles and vesicles. It plays a key role in maintaining the Golgi apparatus structure by tethering this organelle to microtubules. The Golgi apparatus is responsible for modifying, sorting, and packaging proteins and lipids for transport within the cell.

Additionally, HOOK3 is involved in the endocytic pathway, which is the process by which cells internalize molecules from their surface. This is achieved through the formation of vesicles that bud inward from the plasma membrane, a process in which HOOK3 is thought to participate.Abnormalities in HOOK3 function can lead to disruptions in intracellular transport and organelle function, potentially contributing to various cellular dysfunctions and diseases. For instance, mutations in HOOK3 have been implicated in certain neurodegenerative diseases.In summary, HOOK3 is a microtubule-tethering protein with important roles in maintaining cellular structure and facilitating intracellular transport.