Date published: 2025-10-17

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Homobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of homobifunctional crosslinkers for use in various applications. Homobifunctional crosslinkers are chemical reagents that possess two identical reactive groups, enabling them to covalently link two similar functional groups within or between molecules. These crosslinkers are crucial in scientific research for studying protein-protein interactions, stabilizing protein structures, and creating multi-subunit complexes. Researchers utilize homobifunctional crosslinkers to investigate the spatial organization and dynamics of macromolecular assemblies, providing insights into the structural and functional relationships within biological systems. These crosslinkers are also employed in the development of biomaterials, where they enhance the mechanical properties and stability of synthetic polymers and hydrogels. In addition, homobifunctional crosslinkers play a significant role in immobilizing enzymes and other bioactive molecules onto solid supports, facilitating their use in biosensors, bioassays, and biocatalysis. By offering a comprehensive selection of high-quality homobifunctional crosslinkers, Santa Cruz Biotechnology supports advanced research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving innovations in the understanding of molecular interactions and the development of new biotechnological applications. View detailed information on our available homobifunctional crosslinkers by clicking on the product name.

Items 51 to 60 of 60 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane

55400-73-2sc-208714
1 g
$320.00
(0)

1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane is a homobifunctional reagent featuring two methanesulfonyloxy groups that enhance its reactivity towards nucleophiles. This compound exhibits unique molecular interactions, enabling selective coupling with hydroxyl and amine functionalities. Its distinct reaction pathways allow for rapid formation of sulfonate esters, facilitating the synthesis of complex structures. The compound's stability and reactivity profile make it suitable for diverse applications in organic synthesis.

Bis[2-(succinimidooxycarbonyloxy)ethyl] Sulfone

57683-72-4sc-210948
25 mg
$306.00
(0)

Bis[2-(succinimidooxycarbonyloxy)ethyl] sulfone is a homobifunctional reagent characterized by its dual succinimidooxycarbonyloxy groups, which promote efficient cross-linking with nucleophiles. This compound exhibits unique reactivity, enabling the formation of stable amide bonds through its electrophilic sites. Its distinct kinetic behavior allows for controlled reaction rates, making it ideal for precise modifications in polymer chemistry and materials science. The compound's solubility and compatibility with various solvents further enhance its versatility in synthetic applications.

(+/-)-trans-1,2-Bis(chloroacetamido)cyclohexane

150576-46-8sc-213079
250 mg
$300.00
(0)

(+/-)-trans-1,2-Bis(chloroacetamido)cyclohexane is a homobifunctional compound featuring two reactive chloroacetamido groups that facilitate selective conjugation with nucleophiles. Its unique cyclohexane structure introduces steric effects that influence reaction kinetics, allowing for tailored reactivity profiles. The compound's ability to form stable amide linkages enhances its utility in diverse synthetic pathways, while its solubility in organic solvents broadens its applicability in various chemical environments.

1,14-Diazido-3,6,9,12-tetraoxatetradecane

182760-73-2sc-206217
250 mg
$388.00
(0)

1,14-Diazido-3,6,9,12-tetraoxatetradecane is a homobifunctional compound characterized by its dual azide groups, which enable efficient click chemistry reactions. The presence of multiple ether linkages contributes to its unique solubility properties, facilitating interactions with a variety of substrates. Its structural symmetry allows for predictable reactivity, while the azide moieties can engage in diverse coupling reactions, enhancing its versatility in synthetic applications.

Heptaoxatricosanedioic Acid Bis(N-Hydroxysuccinimide) Ester

211746-85-9sc-211585
25 mg
$360.00
(0)

Heptaoxatricosanedioic Acid Bis(N-Hydroxysuccinimide) Ester is a homobifunctional compound distinguished by its dual N-hydroxysuccinimide ester functionalities, which promote selective amine coupling. The presence of multiple ester linkages enhances its reactivity, allowing for efficient conjugation with biomolecules. Its elongated structure and hydrophilic character facilitate solvation and interaction with various substrates, making it a versatile tool in chemical synthesis and bioconjugation.

3,6,9-Trioxaundecane-1,11-diyl-bismethanethiosulfonate

212262-02-7sc-209728
10 mg
$380.00
(0)

3,6,9-Trioxaundecane-1,11-diyl-bismethanethiosulfonate is a homobifunctional compound characterized by its unique bismethanethiosulfonate groups, which enable robust thiol-mediated reactions. The compound's extended ether backbone enhances its solubility and flexibility, promoting effective molecular interactions. Its distinct reactivity profile allows for efficient cross-linking and conjugation, making it suitable for diverse applications in polymer chemistry and materials science.

3,6-Dioxaoctane-1,8-diyl Bismethanethiosulfonate

212262-04-9sc-209726
10 mg
$360.00
(0)

3,6-Dioxaoctane-1,8-diyl Bismethanethiosulfonate is a homobifunctional molecule featuring dual bismethanethiosulfonate moieties that facilitate selective thiol reactions. The compound's unique ether linkages contribute to its enhanced molecular mobility and compatibility with various substrates. Its reactivity is characterized by rapid thiol-disulfide exchange kinetics, enabling efficient formation of stable cross-linked networks, which is advantageous in the development of advanced materials and polymer systems.

3,6,9,12-Tetraoxatetradecane-1,14-diyl-bis-methanethiosulfonate

212262-08-3sc-209729
10 mg
$388.00
(0)

3,6,9,12-Tetraoxatetradecane-1,14-diyl-bis-methanethiosulfonate is a homobifunctional compound distinguished by its extended ether backbone, which enhances solubility and flexibility. The presence of two methanethiosulfonate groups allows for efficient thiol-mediated reactions, promoting robust cross-linking. Its unique structural features facilitate specific molecular interactions, leading to tailored reaction pathways and improved kinetics in polymerization processes, making it a versatile tool in material science.

1,6-Hexane-bis-[3-(2-pyridyldithio)propionamide]

359435-46-4sc-208807
25 mg
$300.00
(0)

1,6-Hexane-bis-[3-(2-pyridyldithio)propionamide] is a homobifunctional compound characterized by its dual pyridyldithio moieties, which enable selective thiol-disulfide exchange reactions. This compound exhibits unique reactivity due to the spatial arrangement of its functional groups, promoting efficient cross-linking and stabilization in various environments. Its distinct molecular interactions enhance the kinetics of conjugation reactions, making it a valuable asset in the development of complex molecular architectures.

Dimethyl suberimidate dihydrochloride

34490-86-3sc-239782
5 g
$78.00
(0)

Dimethyl suberimidate dihydrochloride is a homobifunctional reagent characterized by its imidate groups, which enable selective coupling with nucleophiles. Its unique structure allows for efficient formation of stable linkages, facilitating the creation of complex biomolecular architectures. The compound's reactivity is influenced by its ability to undergo rapid acylation reactions, promoting diverse cross-linking pathways. Additionally, its solubility in various solvents enhances its versatility in synthetic applications.