HNF-1β Inhibitors
Common HNF-1β Inhibitors include, but are not limited to BI 6015 CAS 93987-29-2, Tanshinone IIA CAS 568-72-9, Benzimidazole CAS 51-17-2, AS 1842856 CAS 836620-48-5 and Pyrrole-2-carboxylic acid CAS 634-97-9.
HNF-1β inhibitors belong to a specific class of chemical compounds that are designed to target and inhibit the activity of the Hepatocyte Nuclear Factor-1β (HNF-1β) protein. HNF-1β is a critical component of gene regulation, playing a vital role in controlling the expression of genes involved in various biological processes, such as organ development and metabolism. It is particularly important for the proper development and function of essential organs like the liver, kidney, and pancreas.
HNF-1β exerts its effects by binding to specific regions of DNA and influencing the transcription of target genes. However, disruptions in the HNF-1β gene or its function can lead to a range of developmental abnormalities and metabolic disorders. HNF-1β inhibitors work by specifically targeting this transcription factor, interfering with its ability to bind to DNA and regulate gene expression. As research into HNF-1β and its inhibitors progresses, a deeper understanding of its molecular functions and applications in the context of gene regulation and cellular processes may emerge. The study of HNF-1β inhibitors represents a compelling area of research with the to shed light on the intricate mechanisms underlying gene expression regulation and its impact on organ development and metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BI 6015 | 93987-29-2 | sc-503543 | 10 mg | $380.00 | ||
Selective HNF-1β antagonist that disrupts the interaction between HNF-1β and its coactivators, thereby inhibiting transcriptional activation and modulating gene expression related to liver development and function. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Downregulates HNF-1β expression through inhibition of its upstream regulators, leading to reduced insulin resistance and improvement in glucose metabolism in hepatocytes. | ||||||
Benzimidazole | 51-17-2 | sc-280611 sc-280611A sc-280611B sc-280611C sc-280611D | 50 g 250 g 500 g 1 kg 5 kg | $63.00 $236.00 $316.00 $367.00 $520.00 | ||
Downregulates HNF-1β expression by inhibiting its transcriptional regulators, leading to the modulation of hepatic gene expression and glucose homeostasis. | ||||||
AS 1842856 | 836620-48-5 | sc-507096 sc-507096A | 10 mg 50 mg | $99.00 $415.00 | ||
Inhibits HNF-1β by disrupting its interaction with coactivator p300, leading to impaired transcriptional activation and alteration of hepatic gene expression. | ||||||
BI 9564 | 1883429-22-8 | sc-507350 | 1 mg | $83.00 | ||
Small-molecule inhibitor of HNF-1β DNA-binding activity, leading to the suppression of target genes involved in hepatic lipid and glucose metabolism. | ||||||
Pyrrole-2-carboxylic acid | 634-97-9 | sc-250821 | 1 g | $39.00 | ||
Modulates HNF-1β expression by targeting upstream regulators, leading to the altered expression of hepatic genes involved in glucose and lipid metabolism. | ||||||