Date published: 2026-6-27

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HMGCR Antibodies

Santa Cruz Biotechnology delivers a wide array of HMGCR monoclonal antibodies for research in cholesterol metabolism and related pathways. HMGCR monoclonal antibodies are compatible with multiple techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a crucial role in the mevalonate pathway, which is essential for the biosynthesis of cholesterol and other isoprenoids. As a key regulatory enzyme, HMGCR is a target for statin drugs, which are widely used to manage cholesterol levels and reduce cardiovascular risk. Understanding the function and regulation of HMGCR is vital for advancing therapeutic strategies in lipid disorders and metabolic diseases. HMGCR research has significant implications for cardiovascular health and metabolic regulation. Investigating HMGCR activity patterns helps reveal new insights into cholesterol synthesis pathways. Current research focuses on understanding how HMGCR regulation affects various metabolic conditions. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing our understanding of cholesterol metabolism and its impact on human health.

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HMGCR Antibodies

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HMGCR Antibody (C-1)

sc-271595mouse IgG1 κ589-888 (h)WB, IP, IF, IHC(P), ELISAm, r, h
66
(21)

HMGCR siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

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HMGCR siRNA (h)

sc-43838hGene SilencingN/A
3
(0)

HMGCR shRNA Plasmid (h)

sc-43838-SHhGene SilencingPuromycin
3
(0)

HMGCR shRNA (h) Lentiviral Particles

sc-43838-VhGene SilencingPuromycin
3
(0)

HMGCR siRNA (m)

sc-44851mGene SilencingN/A
1
(0)

HMGCR shRNA Plasmid (m)

sc-44851-SHmGene SilencingPuromycin
1
(0)

HMGCR shRNA (m) Lentiviral Particles

sc-44851-VmGene SilencingPuromycin
1
(0)

HMGCR Transfected Lysates

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HMGCR (m2): 293T Lysate

sc-120842m20
(0)

HMGCR CRISPR Knockout (KO) and HDR Plasmids

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HMGCR CRISPR/Cas9 KO Plasmid (h)

sc-400560Gene Knockouth0
(0)

HMGCR HDR Plasmid (h)

sc-400560-HDRHomology Directed Repairh0
(0)

HMGCR CRISPR/Cas9 KO Plasmid (m)

sc-420877Gene Knockoutm0
(0)

HMGCR HDR Plasmid (m)

sc-420877-HDRHomology Directed Repairm0
(0)

HMGCR CRISPR Double Nickase Plasmids

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HMGCR Double Nickase Plasmid (h)

sc-400560-NICGene Knockouth0
(0)

HMGCR Double Nickase Plasmid (h2)

sc-400560-NIC-2Gene Knockouth0
(0)

HMGCR CRISPR Activation Plasmids and Lentiviral Particles

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HMGCR CRISPR Activation Plasmid (h)

sc-400560-ACTGene Activationh0
(0)

HMGCR CRISPR Activation Plasmid (h2)

sc-400560-ACT-2Gene Activationh0
(0)

HMGCR CRISPR Activation Plasmid (m)

sc-420877-ACTGene Activationm0
(0)