Histone cluster 1 H3D Inhibitors
Histone cluster 1 H3D inhibitors are a class of compounds that specifically target the histone protein, particularly the H3D variant, which is part of the histone cluster 1 family. Histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. These nucleosomes serve as the primary building blocks of chromatin, which is essential for the compact folding of genomic DNA. The core histones include H2A, H2B, H3, and H4, and they play an integral role in the structure of chromatin. Each nucleosome is composed of a segment of DNA wound around eight histone proteins (two each of H2A, H2B, H3, and H4). This winding and packaging mechanism allows the long DNA molecules to fit inside the cell nucleus. The H3D variant is one of the many variants of the H3 histone, and it has specific features that distinguish it from other H3 variants.
The importance of the histone proteins, and in particular the H3D variant, extends beyond mere structural roles. Histones are also key players in the regulation of gene expression. Post-translational modifications (PTMs) of histones, such as methylation, acetylation, and phosphorylation, can lead to either activation or repression of gene expression. Histone cluster 1 H3D inhibitors specifically interact with the H3D variant, modulating its function or its susceptibility to PTMs. The precise modulation of histone function or PTMs can have profound implications for cellular processes, ranging from DNA repair and replication to cellular differentiation. Understanding the interaction of these inhibitors with the H3D variant is of great significance in the broader context of molecular biology and genetics, as it offers insights into the intricate mechanisms of chromatin remodeling and gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
A selective inhibitor of G9a histone methyltransferase. G9a is responsible for methylating H3K9, which is a mark of gene repression. By inhibiting G9a, BIX-01294 reduces H3K9 methylation and can lead to gene activation. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
An inhibitor of EZH2 histone methyltransferase. EZH2 methylates H3K27, which is another mark of gene repression. By inhibiting EZH2, EPZ-6438 reduces H3K27 methylation and can impact gene expression. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
Another inhibitor of EZH2 histone methyltransferase. Similar to EPZ-6438, it reduces the methylation of H3K27 by inhibiting EZH2. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
A pan-selective Jumonji histone demethylase inhibitor. The Jumonji family demethylates various histone H3 lysine residues. By inhibiting these enzymes, JIB-04 affects the methylation status of multiple H3 residues. | ||||||
GSK J1 | 1373422-53-7 | sc-391113 sc-391113A | 10 mg 50 mg | $193.00 $813.00 | ||
A selective inhibitor of the Jumonji H3K27 demethylases JMJD3 and UTX. By inhibiting these enzymes, GSK-J1 increases the methylation status of H3K27. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
An EZH2 histone methyltransferase inhibitor, similar in function to EPZ-6438 and GSK126. It targets the methylation of H3K27. | ||||||