HGFL Activators

Hepatocyte Growth Factor-Like protein (HGFL), also known as Macrophage-Stimulating Protein (MSP), is a serum protein produced predominantly by the liver. It plays a significant role in various physiological processes, including tissue regeneration, immune response, and embryonic development.HGFL is a member of the plasminogen-related growth factor family and functions as a ligand for the Ron receptor tyrosine kinase (also known as MST1R). It is synthesized as a single-chain inactive precursor that is cleaved into a biologically active, disulfide-linked two-chain entity. The alpha chain of HGFL binds to the Ron receptor, and the beta chain is responsible for the protein's activation.

Upon binding and activation, HGFL initiates a cascade of intracellular signals leading to various cellular responses. These responses include cell proliferation, motility, survival, and differentiation, which are crucial for tissue repair and regeneration.Interestingly, HGFL and the Ron receptor have been implicated in cancer pathogenesis. Abnormal activation of the Ron receptor by HGFL has been observed in various cancers, leading to tumor growth, invasion, and metastasis. This makes HGFL a potential target for intervention in cancer.Further, HGFL plays a role in immune regulation, with studies showing its involvement in the suppression of inflammatory responses and the promotion of tissue repair during inflammation.