Date published: 2025-9-25

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Heterobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of heterobifunctional crosslinkers for use in various applications. Heterobifunctional crosslinkers are versatile chemical reagents that possess two different reactive groups, allowing them to link two distinct molecules or surfaces. These crosslinkers are crucial in scientific research for studying and manipulating molecular interactions, creating conjugates, and developing advanced biomaterials. Researchers utilize heterobifunctional crosslinkers to investigate protein-protein, protein-DNA, and protein-ligand interactions, providing insights into cellular signaling pathways, structural biology, and enzymatic functions. They are also used to immobilize biomolecules on various surfaces for biosensor development, drug delivery systems, and diagnostic assays. The ability to selectively and efficiently join different molecules makes these crosslinkers invaluable for designing complex molecular architectures and enhancing the functionality of biomaterials. By providing a comprehensive selection of high-quality heterobifunctional crosslinkers, Santa Cruz Biotechnology supports cutting-edge research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving advancements in our understanding of molecular interactions and the development of innovative biotechnological applications. View detailed information on our available heterobifunctional crosslinkers by clicking on the product name.

Items 11 to 20 of 56 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester

68181-17-9sc-209453
100 mg
$390.00
1
(0)

3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester is a heterobifunctional compound featuring a pyridyldithio group that enables selective disulfide bond formation, facilitating the conjugation of biomolecules. Its succinimidyl ester moiety promotes rapid and efficient coupling with amines, leading to stable amide linkages. This compound's unique reactivity allows for tailored modifications in complex molecular architectures, enhancing the precision of chemical synthesis and bioconjugation strategies.

4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester

79886-55-8sc-252087
25 mg
$112.00
(0)

4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester is a heterobifunctional reagent characterized by its maleimide and N-hydroxysuccinimide functionalities. The maleimide group selectively reacts with thiol-containing compounds, forming stable thioether bonds, while the N-hydroxysuccinimide moiety facilitates efficient coupling with amines. This dual reactivity enables precise control over conjugation processes, making it ideal for creating complex biomolecular constructs with tailored properties.

4-Maleimidobutyric Acid N-Succinimidyl Ester

80307-12-6sc-210101
100 mg
$297.00
(0)

4-Maleimidobutyric Acid N-Succinimidyl Ester is a versatile heterobifunctional compound featuring distinct reactive groups that enable selective conjugation. The maleimide moiety exhibits a strong affinity for thiol groups, promoting the formation of stable thioether linkages, while the succinimidyl ester facilitates rapid and efficient reactions with amines. This unique dual reactivity allows for the strategic assembly of biomolecules, enhancing specificity and stability in various applications.

4-[3-(Trifluoromethyl)diazirin-3-yl]benzoic Acid N-Hydroxysuccinimide Ester

87736-89-8sc-209897A
sc-209897
sc-209897B
sc-209897C
sc-209897D
1 mg
2.5 mg
5 mg
10 mg
25 mg
$230.00
$290.00
$513.00
$940.00
$2000.00
(0)

4-[3-(Trifluoromethyl)diazirin-3-yl]benzoic Acid N-Hydroxysuccinimide Ester is a heterobifunctional compound characterized by its unique trifluoromethyl diazirine group, which enables photochemical activation for covalent bonding upon UV exposure. The N-hydroxysuccinimide ester facilitates efficient coupling with amines, promoting selective conjugation. This compound's distinct reactivity and photoreactivity allow for precise manipulation of molecular interactions, enhancing the versatility of bioconjugation strategies.

4-(N-Succinimidylcarboxy)benzophenone

91990-88-4sc-209864
25 mg
$311.00
(0)

4-(N-Succinimidylcarboxy)benzophenone is a heterobifunctional compound distinguished by its ability to engage in selective cross-linking through its succinimidyl ester and benzophenone moieties. The benzophenone group enables photoinitiated reactions, allowing for covalent bond formation upon UV irradiation. This compound's unique reactivity profile facilitates targeted conjugation with nucleophiles, enhancing the specificity and efficiency of molecular interactions in various applications.

N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate

126695-58-7sc-208056
sc-208056A
50 mg
100 mg
$189.00
$199.00
(0)

N-Succinimidyl 4-Azido-2,3,5,6-tetrafluorobenzoate is a heterobifunctional reagent characterized by its azide and succinimidyl functionalities. The azide group allows for click chemistry, enabling rapid and selective reactions with alkynes under mild conditions. Its tetrafluorobenzoate structure enhances lipophilicity and stability, promoting efficient conjugation with biomolecules. This compound's unique reactivity and stability profile make it a versatile tool for precise molecular labeling and modification.

SASD

144650-95-3sc-220093
10 mg
$330.00
(0)

SASD is a heterobifunctional reagent featuring distinct acid halide and electrophilic functionalities. Its acid halide moiety facilitates acylation reactions, promoting the formation of stable amide bonds with nucleophiles. The compound exhibits high reactivity due to its electrophilic nature, allowing for rapid conjugation with various substrates. Additionally, its unique steric and electronic properties enhance selectivity in complex biochemical environments, making it a powerful tool for targeted modifications.

6-Maleimidocaproic Acid Hydrazide, Trifluoroacetic Acid

151038-94-7sc-210528
50 mg
$245.00
(0)

6-Maleimidocaproic Acid Hydrazide, Trifluoroacetic Acid is a versatile heterobifunctional compound characterized by its maleimide and hydrazide groups. The maleimide moiety enables selective thiol conjugation, while the hydrazide functionality allows for efficient formation of hydrazone linkages. This dual reactivity promotes intricate molecular interactions, enhancing specificity in bioconjugation processes. Its unique structural features facilitate diverse reaction pathways, making it suitable for complex biochemical applications.

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate

158913-22-5sc-212962
10 mg
$190.00
(0)

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate is a heterobifunctional reagent distinguished by its succinimidyl and pyridyldithio groups. The succinimidyl moiety facilitates efficient amine coupling, while the pyridyldithio component enables selective disulfide bond formation. This dual functionality promotes unique molecular interactions, allowing for precise conjugation strategies. Its distinct reactivity profiles enhance the versatility of bioconjugation techniques, supporting complex molecular assemblies.

4-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide, Trifluoroacetic Acid

181148-00-5sc-209848
10 mg
$330.00
(0)

4-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide, Trifluoroacetic Acid is a heterobifunctional compound characterized by its maleimide and hydrazide functionalities. The maleimide group exhibits a strong reactivity towards thiols, facilitating the formation of stable thioether linkages. Meanwhile, the hydrazide moiety allows for selective reactions with carbonyl compounds, enabling versatile conjugation pathways. This unique combination of reactive sites enhances its utility in creating tailored molecular architectures and complex bioconjugates.