Hephaestin Inhibitors
Hephaestin inhibitors are chemical compounds that specifically target and inhibit the function of hephaestin, a copper-dependent ferroxidase enzyme that plays a crucial role in iron metabolism. Hephaestin is primarily involved in the oxidation of ferrous iron (Fe²⁺) to ferric iron (Fe³⁺), a necessary step for the efficient export of iron from cells, particularly enterocytes, into the bloodstream. This enzymatic activity is critical for maintaining iron homeostasis in the body. Inhibitors of hephaestin act by blocking its ability to oxidize iron, thereby interfering with iron export and potentially altering iron distribution within cells and tissues.
By inhibiting hephaestin, researchers can study the effects of disrupted iron metabolism and the mechanisms that regulate iron absorption and distribution at the cellular level. These inhibitors are valuable tools for investigating the role of hephaestin in maintaining proper iron levels and for exploring the broader network of proteins involved in iron transport and storage. Hephaestin inhibitors can also be used to analyze how changes in iron oxidation affect cellular processes such as iron uptake, storage, and utilization. Through these studies, scientists gain a deeper understanding of how hephaestin contributes to iron regulation and the dynamic balance of metal ions within biological systems. These inhibitors provide a means of exploring the specific functions of hephaestin in various tissues and the complex pathways it influences.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $255.00 | ||
Deferoxamine sequesters iron, potentially leading to a downregulation of Hephaestin as the cellular need for iron efflux diminishes in response to perceived iron sufficiency. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG may suppress the transcriptional activity of genes involved in iron metabolism by interfering with transcription factors, potentially leading to a decrease in Hephaestin mRNA synthesis. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Gallotannin′s iron-binding properties could lead to a cellular state mimicking iron abundance, which may trigger a decrease in Hephaestin expression to slow iron transport. | ||||||
Zinc Protoporphyrin-9 | 15442-64-5 | sc-200329 sc-200329A | 25 mg 100 mg | $78.00 $213.00 | 31 | |
Zinc protoporphyrin IX′s inhibition of heme synthesis could initiate a cascade of events culminating in the downregulation of Hephaestin to conserve iron for essential processes. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Lead(II) acetate′s interference with iron absorption and utilization pathways could lead to a compensatory reduction in Hephaestin expression as the body attempts to mitigate iron dysregulation. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium chloride exposure may initiate a cellular stress response that includes the inhibition of non-essential iron export mechanisms, thus reducing Hephaestin levels. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide may induce a downregulation of Hephaestin through gene expression repression mechanisms triggered as a defense against arsenic-induced oxidative stress. | ||||||
Sodium arsenite, 0.1N Standardized Solution | 7784-46-5 | sc-301816 | 500 ml | $130.00 | 4 | |
Sodium arsenite could lead to the inhibition of Hephaestin expression by triggering cellular pathways that aim to minimize arsenic toxicity, including those governing iron homeostasis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D (Dactinomycin) binds tightly to DNA, preventing RNA polymerase from progressing, which would directly lead to decreased transcription of Hephaestin mRNA. | ||||||