HAGHL Activators
Taxol and Docetaxel, both microtubule stabilizers, work by binding to β-tubulin, enhancing the structural stability of microtubules and potentially supporting the role of HAUS6 in spindle function. This stabilization can enhance HAUS6's role in spindle dynamics. Conversely, compounds like Vincristine, Nocodazole, and Colchicine, which disrupt microtubule polymerization, create a cellular environment that could necessitate the compensatory activity of HAUS6 in spindle assembly and checkpoint control. Their action can lead to a cascade of cellular responses where HAUS6's activity becomes crucial for correcting perturbations in the microtubule architecture.
Podophyllotoxin, Eribulin, Griseofulvin, Vinblastine, Vinflunine, and Vinorelbine share a common theme in their modes of action-they all interfere with microtubule dynamics, albeit through different mechanisms. Podophyllotoxin prevents tubulin assembly into microtubules, which could indirectly affect HAUS6's function in organizing these structures. Eribulin and Griseofulvin disrupt the growth of microtubules and, as a result, could impact HAUS6's role in cell division. Vinblastine, Vinflunine, and Vinorelbine also modulate the stability of microtubules, but through a mechanism that inhibits tubulin assembly into microtubules, necessitating HAUS6's involvement in the reassembly of the spindle apparatus.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules by binding to β-tubulin and can indirectly maintain the integrity of the mitotic spindle, possibly affecting HAUS6 function. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $85.00 $325.00 $1072.00 | 16 | |
Docetaxel stabilizes microtubules, potentially supporting HAUS6-related microtubule dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule polymerization and can lead to cellular responses that indirectly involve HAUS6 activity due to changes in microtubule dynamics. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin, preventing microtubule polymerization, which may indirectly affect HAUS6 function during cell cycle progression. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Inhibits microtubule assembly and can indirectly impact HAUS6 activity through altered microtubule dynamics. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Inhibits the growth phase of microtubules, potentially affecting HAUS6 function in spindle assembly. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Disrupts microtubule function, which could indirectly influence HAUS6-associated processes. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Inhibits microtubule formation, possibly affecting HAUS6 indirectly by disrupting spindle microtubule dynamics. | ||||||
Vinflunine | 162652-95-1 | sc-507411 | 10 mg | $390.00 | ||
Disrupts microtubule dynamics, which could in turn influence HAUS6 activity. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $28.00 $79.00 $255.00 $775.00 $1938.00 | ||
A microtubule destabilizer that could indirectly modulate HAUS6 function. | ||||||