Gtlf3b Activators
Glutamate receptor ionotropic, NMDA 3B (GRIN3B) Activators encompass a variety of chemical compounds that indirectly influence GRIN3B's functional activity through different molecular mechanisms. D-serine and glycine are crucial co-agonists that directly bind to GRIN3B, facilitating receptor activation and enhancing calcium ion permeability. Spermine and polyamines, including their derivatives, serve as positive allosteric modulators, increasing the sensitivity of the receptor to its primary agonist, glutamate, which results in an escalated conductance of calcium ions. Zinc ions at low concentrations and pregnenolone sulfate also function as allosteric modulators, fine-tuning the receptor's sensitivity and activity. Furthermore, magnesium's role as a voltage-dependent blocker indirectly augments GRIN3B activity upon cellular depolarization by allowing ion flow, and Ivermectin, by binding to a site distinct from the glutamate binding site, enhances ion permeability through the receptor.
The dynamic regulation of GRIN3B activity is further modulated by specific compounds that target the receptor's associated signaling pathways. Ifenprodil, at particular concentrations, can exert a modulatory effect on GRIN3B, fine-tuning the receptor's response to neurotransmitters and altering calcium ion flux through the receptor channel. Cis-4-Aminocrotonic acid (CACA), as a partial agonist at the glycine modulatory site, mimics the action of glycine, thereby promoting receptor activation and enhancing the channel's ion conductance. The influence of the neurosteroid Huperzine A is exerted through the inhibition of acetylcholinesterase, leading to increased acetylcholine levels that can modulate NMDA receptor activity, including that of GRIN3B, through interactions with nicotinic receptors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Serine | 312-84-5 | sc-391671 sc-391671A sc-391671B | 5 g 25 g 100 g | $43.00 $128.00 $204.00 | ||
As an endogenous co-agonist for NMDA receptors, D-serine binds to the co-agonist site on GRIN3B, leading to the enhancement of its channel opening probability and increasing calcium influx. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine serves as a required co-agonist for NMDA receptor activation. By binding to its site on GRIN3B, glycine facilitates receptor activation, enhancing the likelihood of channel opening and subsequent calcium conductance. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine acts as a positive allosteric modulator of NMDA receptors. Its binding to GRIN3B increases receptor sensitivity to glutamate, thereby enhancing channel activation and calcium ion permeability. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions modulate NMDA receptor activity by binding to an allosteric site. At low concentrations, zinc enhances GRIN3B receptor function, potentially increasing channel opening events. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
Ivermectin is a positive allosteric modulator of NMDA receptors. It binds to a site distinct from the glutamate binding site on GRIN3B, enhancing its receptor activity and increasing ion permeability. | ||||||
Ifenprodil hemitartrate | 23210-58-4 | sc-203601B sc-203601 sc-203601A | 5 mg 10 mg 50 mg | $39.00 $61.00 $142.00 | ||
Ifenprodil selectively inhibits NMDA receptors containing the GRIN3B subunit. At sub-inhibitory concentrations, it can modulate receptor activity, leading to an enhancement of calcium ion flux. | ||||||
(−)-Huperzine A | 102518-79-6 | sc-200183 sc-200183A | 1 mg 5 mg | $143.00 $362.00 | 1 | |
Huperzine A indirectly enhances NMDA receptor function, including GRIN3B, by inhibiting acetylcholinesterase and increasing acetylcholine levels, which can modulate NMDA receptor activity through nicotinic acetylcholine receptors. | ||||||
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $99.00 | 2 | |
Pregnenolone sulfate is a neurosteroid that can act as a positive allosteric modulator at NMDA receptors. It binds to GRIN3B and enhances receptor function, facilitating calcium influx. | ||||||
Cyclothiazide | 2259-96-3 | sc-202560 sc-202560A | 10 mg 50 mg | $107.00 $227.00 | 3 | |
Cyclothiazide acts on AMPA receptors to prevent desensitization, which leads to increased glutamatergic signaling. This can indirectly enhance GRIN3B activity by increasing the likelihood of receptor co-activation with glutamate. | ||||||