Date published: 2025-12-24

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GPR25 Inhibitors

GPR25 inhibitors represent a class of chemical compounds designed to target and modulate the activity of the G-protein coupled receptor 25, also known as GPR25. GPR25 is a member of the GPCR family, a diverse group of cell surface receptors that play critical roles in cellular signaling processes. These receptors are involved in transmitting signals from extracellular molecules, such as hormones and neurotransmitters, to the interior of the cell, ultimately leading to a wide range of physiological responses. GPR25, specifically, is an orphan receptor, meaning its endogenous ligands and natural functions remain largely unknown. However, it is expressed in various tissues throughout the body, including the central nervous system, gastrointestinal tract, and immune system, suggesting its potential importance in regulating various physiological processes. GPR25 inhibitors are synthetic compounds or molecules designed to bind to GPR25 and interfere with its signaling pathways. These inhibitors can act in different ways, including blocking the receptor's activation by potential endogenous ligands or modulating its downstream signaling cascades. By inhibiting GPR25, these compounds have the potential to influence cellular responses in various tissues and may have applications in research and drug development. Understanding the specific functions and downstream effects of GPR25 inhibition is an active area of scientific investigation, and it holds promise for uncovering novel insights into cellular signaling pathways and their potential relevance to various physiological and pathological conditions. Therefore, GPR25 inhibitors represent a valuable tool in basic research, offering the potential to elucidate the functions of this enigmatic receptor and its role in various cellular processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Naloxone

465-65-6sc-477809
200 mg
$300.00
5
(0)

Naloxone is an opioid receptor antagonist that may have some activity against GPR25 due to its broad-spectrum GPCR inhibition.

Naltrexone

16590-41-3sc-477813
sc-477813A
sc-477813B
100 mg
1 g
2.5 g
$340.00
$1353.00
$2400.00
(0)

Like naloxone, naltrexone is an opioid receptor antagonist that may have off-target effects on GPR25.

Propranolol

525-66-6sc-507425
100 mg
$180.00
(0)

Propranolol is a non-selective beta-adrenergic receptor antagonist, but it may also affect other GPCRs, including GPR25.

Cyanopindolol hemifumarate

106469-57-2sc-203906
sc-203906A
10 mg
25 mg
$159.00
$693.00
(0)

Cyanopindolol is a non-selective beta-adrenergic receptor antagonist and a 5-HT1A receptor antagonist, which may have some activity against GPR25.

GR 113808

144625-51-4sc-361189
sc-361189A
10 mg
50 mg
$189.00
$809.00
(0)

It is a selective antagonist for the 5-HT4 receptor and may have limited activity against GPR25.

SB-334867

792173-99-0sc-507323
10 mg
$207.00
(0)

SB-334867 is a selective antagonist of the orexin receptor OX1R, but it may also have some activity against other GPCRs.