Gm266 Inhibitors

Gm266 inhibitors target a variety of biological functions and pathways that are likely to be associated with the activity and regulation of GM266. Bisindolylmaleimide I, for example, is a known inhibitor of protein kinase C (PKC) which plays a crucial role in signal transduction pathways, including those mediated by Rap proteins, which GM266 is predicted to be involved in. NSC23766 is a specific inhibitor of Rac1, a small GTPase involved in cell migration, a process that GM266 is also predicted to regulate. Edelfosine disrupts lipid signaling within the plasma membrane, where GM266 is predicted to be active, potentially perturbing GM266-involved pathways. Mycophenolic Acid, by depleting guanosine nucleotides, can affect GM266's predicted GDP/GTP binding activity. Brefeldin A's disruption of Golgi function can indirectly impact GM266 if its activity or localization is dependent on Golgi-mediated processing or trafficking.

Manumycin A targets the post-translational modification of proteins like Ras, which are upstream of Rap protein signaling, and thus may influence GM266 function. Y-27632 and TNP-470's effects on cell migration can relate to the negative regulation of cell migration by GM266. Lovastatin affects protein prenylation, which is essential for the membrane association of many signaling molecules, and could indirectly affect GM266's membrane localization and function. Ribavirin and GTPγS interfere with the GTPase cycle, either by depleting GTP pools or by acting as a non-hydrolyzable analog, thereby potentially affecting GM266's GTPase activity. CID-1067700, as a generic GTPase inhibitor, can also affect the GTPase function of GM266.