Gm1527 Activators
Given the nature of Gm1527 and its predicted function as a GTPase activator, chemicals that influence the pathways and cellular processes related to GTPases can be considered as indirect activators. Gm1527 activators, therefore, do not activate the protein in the traditional sense by direct binding or allosteric modulation. Instead, their activation mechanism is predicated on altering the cellular environment or the state of GTPases in a manner that necessitates or enhances the activity of Gm1527.
These chemicals typically act on upstream components of signaling pathways or fundamental cellular processes that, in turn, influence the activity of GTPases. For example, compounds that increase intracellular cAMP levels can lead to the activation of PKA, which may phosphorylate and thus modulate proteins involved in GTPase signaling. In scenarios where GTPases are persistently activated, such as with the presence of GTPγS or aluminum fluoride, cellular mechanisms may respond by upregulating GAPs like Gm1527 to restore signaling homeostasis. Similarly, Mn2+ can indirectly promote the function of Gm1527 by enhancing the phosphorylation state of proteins within the GTPase signaling network.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS is a non-hydrolyzable analog of GTP. It binds to GTPases without being hydrolyzed, permanently activating them. This persistent activation may stimulate compensatory regulatory mechanisms within the cell, such as the upregulation of GTPase activating proteins like Gm1527 to restore balance, indirectly increasing the function of Gm1527. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
NaF is an activator of heterotrimeric G proteins by inhibiting their intrinsic GTPase activity. This inhibition leads to prolonged activation of G proteins, which may necessitate the compensatory activation of GAPs like Gm1527 in an effort to terminate the signal, thereby indirectly enhancing the activity of Gm1527. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions (Mn2+) act as cofactors for many enzymes, including kinases that phosphorylate proteins. Phosphorylation can alter the activity of GTPases or the proteins that regulate them. By acting as a cofactor, Mn2+ can indirectly enhance the activity of Gm1527 by promoting the phosphorylation of proteins that interact with or regulate GTPases. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $67.00 $250.00 | ||
AlF4- acts as an analog of the phosphate group and stabilizes the transition state of GTP hydrolysis. By binding to GTP-bound GTPases, it mimics the gamma phosphate of GTP, leading to a form that resembles the transitional state of GTP hydrolysis. This may indirectly enhance the activity of Gm1527 by stabilizing the GTPase in a conformation that is more susceptible to its activating function. | ||||||