Date published: 2026-2-22

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GluR-7 Activators

GluR-7 Activators belong to a distinctive chemical class characterized by their ability to modulate the activity of ionotropic glutamate receptors, specifically those falling under the category of GluR-7. These receptors are integral components of the central nervous system, where they play a crucial role in mediating excitatory neurotransmission. GluR-7, a subtype of the ionotropic glutamate receptor family, is predominantly expressed in various brain regions, including the hippocampus and cerebellum. The activation of GluR-7 is associated with the regulation of synaptic transmission and plasticity. Chemically, GluR-7 Activators interact with the GluR-7 receptor to modulate its function, thereby influencing the excitatory signals transmitted between neurons. The molecular structure of these activators is designed to selectively engage with the GluR-7 receptor, eliciting specific conformational changes that result in altered ion channel conductance. This modulation of ion flow through the receptor has implications for synaptic plasticity and neuronal communication. The development and study of GluR-7 Activators contribute to our understanding of the intricate mechanisms governing neurotransmission and synaptic function. Further research into this chemical class may unravel novel insights into the complex interplay of molecular events underlying neural processes and paves the way for advancements in neuropharmacology.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-Glutamic Acid

56-86-0sc-394004
sc-394004A
10 g
100 g
$297.00
$577.00
(0)

As the primary excitatory neurotransmitter in the brain, glutamate directly activates GluR-7 by binding to the receptor and triggering ion channel opening.

Kainic acid monohydrate

58002-62-3sc-269283
10 mg
$275.00
(1)

Kainic acid is a direct agonist for kainate receptors, including GluR-7, and mimics the effects of glutamate, leading to receptor activation.

(R,S)-ATPA

140158-50-5sc-203232
sc-203232A
sc-203232B
sc-203232C
1 mg
5 mg
10 mg
50 mg
$50.00
$150.00
$209.00
$865.00
(0)

ATPA directly activates GluR5 subunit of kainate receptors, another subunit in the same receptor family as GluR-7, potentially influencing the functioning of the entire kainate receptor complex.

(S)-(-)-5-Iodowillardiine

140187-25-3sc-361327
sc-361327A
10 mg
50 mg
$169.00
$712.00
(0)

5-Iodowillardiine acts as an agonist at AMPA and kainate receptors, directly mimicking the effects of glutamate and potentially activating receptors including GluR-7.

N-Methyl-D-Aspartic acid (NMDA)

6384-92-5sc-200458
sc-200458A
50 mg
250 mg
$109.00
$369.00
2
(1)

NMDA is an agonist for the NMDA glutamate receptor, and while it does not directly activate GluR-7, it affects glutamate signaling system-wide, potentially indirectly influencing GluR-7 functioning.

AMPA

74341-63-2sc-200437
sc-200437A
5 mg
50 mg
$153.00
$796.00
(1)

AMPA is an agonist for the AMPA receptor, another type of glutamate receptor. While it does not directly activate GluR-7, it may indirectly influence GluR-7 by modulating the overall glutamate signaling system.

(-)-MK 801 maleate

77086-19-2sc-361253
sc-361253A
10 mg
50 mg
$59.00
$265.00
(0)

MK-801 is an antagonist for the NMDA receptor. It does not directly activate GluR-7 but by inhibiting NMDA receptors, it could indirectly modulate GluR-7 activity via changes in overall glutamate signaling.

6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-Dione

118876-58-7sc-478080
5 mg
$70.00
1
(0)

NBQX is an AMPA receptor antagonist and does not directly activate GluR-7. However, by modulating glutamate signaling via AMPA receptors, it could indirectly affect GluR-7 activity.

Memantine hydrochloride

41100-52-1sc-203628
50 mg
$69.00
4
(2)

Memantine is an NMDA receptor antagonist. While it does not directly activate GluR-7, its modulation of glutamate signaling through NMDA receptors might indirectly affect GluR-7.