γ1 Tubulin Inhibitors
Chemical inhibitors of γ1 Tubulin affect the protein by interfering with its role in microtubule dynamics. Colchicine, Vinblastine, and Vincristine are notable for their ability to bind tubulin, inhibiting its polymerization into microtubules. This inhibition can initiate a cellular response that activates γ1 Tubulin to stabilize microtubule formation and maintain cellular functions. Similarly, Nocodazole disrupts microtubule polymerization by binding to β-tubulin, which can trigger the activation of γ1 Tubulin as a cellular response to maintain microtubule integrity. 2-Methoxyestradiol operates by binding to tubulin at the colchicine binding site, thus affecting microtubule dynamics. This interaction can activate γ1 Tubulin by promoting its participation in microtubule assembly, aiding in the preservation of cell structure and intracellular transport processes.
Conversely, several chemicals promote the activation of γ1 Tubulin by enhancing microtubule polymerization. Paclitaxel and Taxol both bind to the β-tubulin subunit, promoting microtubule stabilization and, concurrently, can activate γ1 Tubulin by driving its inclusion in the microtubule polymerization process. Docetaxel shares a similar mechanism, promoting microtubule assembly by stabilizing microtubules and preventing depolymerization, which can lead to the activation of γ1 Tubulin. Epothilone B, Peloruside A, Laulimalide, and Discodermolide also stabilize microtubules by binding to β-tubulin, which can result in the activation of γ1 Tubulin by promoting its incorporation into microtubules, supporting its role in cellular architecture. These chemicals collectively modulate the activity of γ1 Tubulin through diverse interactions with tubulin and microtubules, either by inhibiting polymerization or promoting stabilization and assembly.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and enhances tubulin polymerization, which can directly lead to the activation of γ1 Tubulin by promoting its assembly into microtubules, thus supporting its structural role in the cytoskeleton. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Docetaxel promotes microtubule assembly by binding to β-tubulin and stabilizing microtubules, preventing depolymerization. This action can lead to the activation of γ1 Tubulin as it enhances the polymerization in which γ1 Tubulin participates. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B binds to β-tubulin subunits on microtubules and leads to microtubule stabilization, which can activate γ1 Tubulin by promoting its incorporation into microtubules and thus supporting its role in microtubule dynamics. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization, leading to a compensatory cellular response that may include the activation of γ1 Tubulin to stabilize microtubule formation and maintain cellular functions. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting tubulin polymerization into microtubules, which can trigger a cellular response that leads to the activation of γ1 Tubulin to support microtubule assembly and cellular architecture. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization by binding to β-tubulin. This disruption may trigger the activation of γ1 Tubulin as a cellular response to maintain microtubule integrity. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide stabilizes microtubules by binding to a site on β-tubulin, which could lead to the activation of γ1 Tubulin by enhancing its incorporation into structurally integral microtubules. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol binds to tubulin at the colchicine binding site, affecting microtubule dynamics. This binding can activate γ1 Tubulin by promoting its participation in microtubule assembly to counteract microtubule destabilization, aiding in the preservation of cell structure and intracellular transport processes. | ||||||