GABAA R rho 1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SK&F 97541 | 127729-35-5 | sc-200469 sc-200469A | 5 mg 25 mg | $101.00 $450.00 | ||
SK&F 97541 acts as a selective modulator of GABAA R rho 1 receptors, characterized by its ability to stabilize receptor conformations through unique hydrophobic interactions. This compound exhibits a distinct binding profile that influences allosteric modulation, leading to altered ion flow dynamics. Its specific steric configuration enhances receptor selectivity, while its lipophilic nature affects membrane interactions, potentially impacting cellular signaling pathways. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin inhibits GABAA Rρ1 by non-competitively blocking the chloride channel associated with the receptor, preventing chloride ion flow that contributes to the inhibitory function of the receptor. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $82.00 $281.00 | ||
Bicuculline serves as a competitive antagonist for GABAA Rρ1 by binding to the GABA site, thus inhibiting GABA-mediated chloride ion influx. | ||||||
Gabazine | 105538-73-6 | sc-211552 | 10 mg | $714.00 | 3 | |
Gabazine inhibits GABAA Rρ1 by competing with GABA for its binding sites on the receptor, thereby preventing the receptor's activation and subsequent chloride ion conductance. | ||||||
Flumazenil (Ro 15-1788) | 78755-81-4 | sc-200161 sc-200161A | 25 mg 100 mg | $110.00 $370.00 | 10 | |
Flumazenil binds to the benzodiazepine site on GABAA Rρ1, antagonizing the effects of benzodiazepines on the receptor which would otherwise enhance the receptor's response to GABA, leading to inhibition of its function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate can inhibit GABAA Rρ1 by binding allosterically to the receptor, which changes the receptor configuration and reduces its sensitivity to GABA, thus decreasing its activity. | ||||||
Penicillin G sodium salt | 69-57-8 | sc-257971 sc-257971A sc-257971B sc-257971C sc-257971D | 1 mg 10 mg 1 g 5 g 100 g | $26.00 $37.00 $47.00 $171.00 $265.00 | 1 | |
Penicillin can block the chloride channel of GABAA Rρ1 at high concentrations, inhibiting the ion flow essential for receptor function. | ||||||
Isoflurane | 26675-46-7 | sc-470926 sc-470926A | 5 g 25 g | $69.00 $219.00 | 7 | |
Isoflurane can induce a state of desensitization in GABAA Rρ1 at high concentrations, making the receptor less responsive to GABA and thereby inhibiting its function. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Furosemide inhibits GABAA Rρ1 by blocking the chloride channel associated with the receptor, particularly at higher concentrations, preventing the necessary chloride ion flow for its inhibitory function. | ||||||