G3PP Inhibitors
G3PP inhibitors primarily function by modulating or interfering with the intricate metabolic pathways, particularly those related to glycolysis and lipid metabolism. G3PP, or glycerol-3-phosphate phosphatase, plays a crucial role in the dephosphorylation of glycerol-3-phosphate to glycerol, integrating carbohydrate and lipid metabolism. Inhibiting this enzyme or its activity directly can impact various cellular functions and energy dynamics.
A range of compounds can interfere with the metabolic pathways that supply or utilize the substrates and products associated with G3PP. For example, 2-Deoxy-D-glucose and 3-Bromopyruvate are known glycolytic inhibitors that can restrict the availability of glycerol-3-phosphate, a direct substrate for G3PP. Other chemicals like Iodoacetate and Lonidamine target specific enzymes in the glycolytic pathway, thus altering the metabolic flux and indirectly affecting G3PP.On the other hand, compounds like Atorvastatin and Etomoxir focus on lipid metabolism, highlighting the tight connection between carbohydrate and lipid metabolic pathways. By modulating lipid metabolism, they indirectly influence the levels of glycerol-3-phosphate and hence, the activity of G3PP.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
This glucose analog inhibits glycolysis, reducing the production of glycerol-3-phosphate. | ||||||
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $57.00 $99.00 | ||
Inhibits the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase, impacting G3PP indirectly. | ||||||
Lonidamine | 50264-69-2 | sc-203115 sc-203115A | 5 mg 25 mg | $105.00 $364.00 | 7 | |
It interferes with the glycolytic pathway by inhibiting hexokinase, affecting G3PP indirectly. | ||||||
Sodium oxamate | 565-73-1 | sc-215880 sc-215880B sc-215880C sc-215880D sc-215880A | 5 g 100 g 250 g 1 kg 25 g | $77.00 $469.00 $1106.00 $4111.00 $152.00 | 14 | |
Lactate dehydrogenase inhibitor that affects pyruvate levels, indirectly influencing G3PP activity. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Affects mitochondrial activity and can influence glycolytic intermediates, indirectly affecting G3PP. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Affects lipid metabolism, which can have indirect effects on glycerol-3-phosphate levels and G3PP. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Inhibits fatty acid oxidation, potentially influencing the glycerol-3-phosphate pool and G3PP. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Alters metabolic profiles and can indirectly modulate glycolytic intermediates and G3PP. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $61.00 $128.00 | 5 | |
Shifts metabolism from glycolysis to glucose oxidation, indirectly influencing G3PP. | ||||||