Chemical activators of FLJ35220 can include a variety of compounds that engage with the protein's activity through different biochemical pathways. Zinc chloride, for example, can enhance the protein's binding to DNA by serving as an allosteric activator, which is crucial for proteins involved in DNA repair processes. Magnesium chloride can similarly support FLJ35220 activity by stabilizing its structure or acting as a cofactor necessary for its enzymatic action. Manganese(II) chloride may also activate FLJ35220 by serving as an essential divalent metal ion, which is a common requirement for the catalytic activity of certain enzymes. Calcium chloride can participate by activating proteins within signal transduction pathways that FLJ35220 may be part of, thereby increasing its functional activity.
Further activation of FLJ35220 can be facilitated by compounds that modulate intracellular signaling mechanisms. Sodium orthovanadate can lead to the activation of FLJ35220 by inhibiting phosphatases, thus promoting a phosphorylated state of proteins that is often associated with increased activity. Forskolin raises the levels of cAMP, which activates protein kinase A (PKA); in turn, PKA can phosphorylate FLJ35220, leading to its activation. Ionomycin, by increasing intracellular calcium, can activate calcium-dependent enzymes that may in turn activate FLJ35220. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which might similarly result in the phosphorylation and activation of FLJ35220. The compound adenosine 5'-triphosphate (ATP) is a substrate for kinases and can be directly utilized to transfer a phosphate group to FLJ35220, triggering its activation. The cAMP analog 8-Bromo-cAMP, by activating PKA, may further support the phosphorylation and activation of FLJ35220. Inhibition of protein phosphatases through okadaic acid and calyculin A can lead to a net increase in the phosphorylation state of FLJ35220, which is frequently associated with enhanced protein activity. These chemicals, through their respective mechanisms, can activate FLJ35220 by impacting its phosphorylation status or by affecting the metal ion availability that is crucial for its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can serve as allosteric activators for some DNA-binding proteins, and FLJ35220 being involved in DNA repair, zinc may facilitate its DNA-binding capacity, leading to its activation. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium is essential for the activity of many enzymes; it can activate FLJ35220 by stabilizing the structure of the enzyme or by acting as a cofactor. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions can activate enzymes that require divalent metal ions for their activity, which can include FLJ35220 if its function is dependent on such ions. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions can activate proteins involved in signal transduction pathways, potentially leading to the activation of FLJ35220 if it is part of such pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
This compound is a phosphatase inhibitor; by inhibiting phosphatases, it may lead to an increased phosphorylation state of proteins like FLJ35220, resulting in its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin raises intracellular calcium levels, which can activate calcium-dependent enzymes that may lead to the activation of FLJ35220. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C which can phosphorylate substrates, potentially including FLJ35220, leading to its activation. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP is the substrate for kinases; the transfer of a phosphate group from ATP to FLJ35220 by kinases could result in the protein's activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
As a cAMP analog, 8-Bromo-cAMP activates PKA; PKA can phosphorylate proteins, potentially leading to the activation of FLJ35220 if it is a substrate for PKA. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which may lead to increased phosphorylation and consequent activation of FLJ35220. | ||||||