Filamin β Inhibitors
Chemical inhibitors of Filamin β can play a role in modulating cell structure and signaling pathways by targeting the protein's interactions with the extracellular matrix (ECM). Marimastat, an inhibitor of matrix metalloproteinases (MMPs), is known to prevent the remodeling of the ECM, which is a crucial process for cellular migration and signaling pathways involving Filamin β. By preventing ECM remodeling, Marimastat can disrupt the mechanical stability and signaling functions that depend on Filamin β. Similarly, SB-3CT, a selective inhibitor of MMP-2 and MMP-9, can impede Filamin β's role in cell motility by disrupting its interaction with the ECM. PD 166793 and Ro 32-3555, both MMP inhibitors, can affect the ECM interactions and potentially inhibit Filamin β's participation in signal transduction and the maintenance of cell structure. Batimastat can also inhibit ECM degradation, affecting the pathways that Filamin β facilitates, such as cell migration and adhesion.
Continuing with the MMP inhibitors, Ilomastat, TAPI-0, TAPI-1, TAPI-2, Prinomastat, and AG3340 (also known as prinomastat), can interfere with ECM turnover, cellular functionalities, and the cleavage of cell surface molecules where Filamin β plays a role. For instance, TAPI-0 and TAPI-1 can inhibit the function of Filamin β in cell migration and invasion by affecting the activity of MMPs and ADAMs, thereby hindering matrix remodeling which is vital for these processes. TAPI-2, by inhibiting the shedding of cell surface receptors, can disrupt processes that involve Filamin β in cell signaling and structural integrity. Lastly, BB-94, as a broad-spectrum MMP inhibitor, can inhibit the degradation of the ECM, thus disrupting the signaling pathways and mechanical stability where Filamin β is implicated. Through these actions, the selected chemicals can inhibit the functional aspects of Filamin β, affecting its role in maintaining cell structure and mediating signal transduction within various cellular contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a matrix metalloproteinase (MMP) inhibitor that could inhibit Filamin β by preventing the remodeling of the extracellular matrix, which is essential for various cellular functions including migration and signaling pathways where Filamin β is involved. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
SB-3CT is a selective inhibitor of MMP-2 and MMP-9. Inhibition of these MMPs could inhibit Filamin β's interaction with the extracellular matrix, thus potentially disrupting signaling pathways where Filamin β participates in cell motility. | ||||||
Ro 32-3555 | 190648-49-8 | sc-296277 | 10 mg | $413.00 | 2 | |
Ro 32-3555 is an MMP inhibitor which could affect the structural integrity of the extracellular matrix, potentially inhibiting the mechanical stability within cells where Filamin β is implicated. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is an MMP inhibitor that could impede the extracellular matrix degradation, potentially inhibiting the pathways that rely on the structural role of Filamin β for cell migration and adhesion. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Ilomastat, also known as GM6001, is an MMP inhibitor which could inhibit the extracellular matrix turnover, thus potentially affecting the cellular functionalities that involve Filamin β in anchoring cytoskeleton to the matrix. | ||||||
TAPI-2 | 187034-31-7 | sc-205851 sc-205851A | 1 mg 5 mg | $286.00 $1019.00 | 15 | |
TAPI-0 is an inhibitor of MMPs and ADAMs (a disintegrin and metalloproteinase domain-containing proteins) which could inhibit the function of Filamin β in processes like cell migration and invasion where matrix remodeling is crucial. | ||||||
TAPI-1 | 171235-71-5 | sc-222337 | 1 mg | $669.00 | 15 | |
TAPI-1 is an inhibitor of MMP and ADAM, which could inhibit the cleavage of cell surface molecules, a process in which Filamin β might be involved through its interaction with the cytoskeleton and signaling molecules. | ||||||
PD 166866 | 192705-79-6 | sc-208154 | 5 mg | $300.00 | 1 | |
Prinomastat is an MMP inhibitor that could inhibit the proteolytic degradation of the extracellular matrix, potentially affecting the cellular processes that rely on Filamin β's role in cell mechanics and signal transduction. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
AG3340, also known as prinomastat, is an MMP inhibitor that could potentially inhibit the interaction between Filamin β and integrins or other extracellular matrix components, affecting cell adhesion and signaling. | ||||||