Date published: 2026-4-11

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FGFR-4 Inhibitors

FGFR-4 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Fibroblast Growth Factor Receptor 4 (FGFR-4). FGFR-4 is a receptor tyrosine kinase that is part of the FGFR family, which plays a critical role in cell proliferation, differentiation, and migration. FGFR-4 is expressed in various tissues and is involved in multiple cellular processes, including organ development, tissue repair, and angiogenesis. FGFR-4 inhibitors work by specifically targeting the FGFR-4 receptor, interfering with its activation and downstream signaling pathways. By doing so, these inhibitors may modulate cellular responses mediated by FGFR-4, affecting processes such as cell growth and tissue homeostasis. Research into FGFR-4 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in cellular signaling. The study of FGFR-4 inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricate mechanisms governing cellular responses to growth factors and their role in tissue development and maintenance.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BGJ398

872511-34-7sc-364430
sc-364430A
sc-364430B
sc-364430C
5 mg
10 mg
50 mg
100 mg
$216.00
$252.00
$594.00
$1009.00
4
(1)

A chemical compound known as an inhibitor of FGFR-4, a receptor tyrosine kinase involved in cell growth and development. By inhibiting FGFR-4, BGJ398 disrupts downstream signaling pathways related to cell proliferation and survival. This compound's inhibitory properties make it valuable for research, allowing scientists to study the role of FGFR-4 in cellular processes without mentioning specific clinical or therapeutic applications.

Debio-1347

1265229-25-1sc-507386
10 mg
$324.00
(0)

Acts as an ATP-competitive inhibitor, binding to the ATP-binding pocket of FGFR-4, inhibiting its kinase activity and downstream signaling in cancer cells.

AZD4547

1035270-39-3sc-364421
sc-364421A
5 mg
10 mg
$198.00
$309.00
6
(1)

Inhibits FGFR-4 by competing with ATP for binding to its kinase domain, leading to inhibition of FGFR-4 signaling and potential anti-cancer effects.

AP 24534

943319-70-8sc-362710
sc-362710A
10 mg
50 mg
$175.00
$983.00
2
(1)

Acts as a multi-targeted kinase inhibitor, including FGFR-4, blocking its activity and interfering with cancer cell proliferation and angiogenesis.

Erdafitinib

1346242-81-6sc-507388
10 mg
$138.00
(0)

Selectively targets FGFR-4, inhibiting its kinase activity and downstream signaling, potentially leading to therapeutic benefits in FGFR-4-driven cancers.