FAM22F Inhibitors

FAM22F inhibitors comprise compounds targeting key components in signaling pathways associated with FAM22F activation. Wortmannin, LY294002, AS605240, GDC-0941, and CAL-101 act on PI3-kinases, disrupting FAM22F phosphorylation through competitive ATP binding. Sotrastaurin, Enzastaurin, A66, and MK-2206 suppress FAM22F by targeting PKC or AKT, interfering with kinase activity and altering downstream signaling. BX795 and GSK2334470 inhibit FAM22F through PDK1 modulation, disrupting kinase activity and subsequent cellular responses. PIK-75 selectively targets PI3-kinases, hindering FAM22F activation by disrupting kinase activity. These inhibitors collectively impede FAM22F-mediated cellular processes, offering potential avenues for exploring the modulation of FAM22F function.