FAM18A Inhibitors
FAM18A, a Golgi apparatus membrane protein associated with TVP23 A, plays a crucial role in the intricate membrane dynamics and protein trafficking processes within the Golgi apparatus. This membrane protein contributes to the proper functioning of the Golgi, a central organelle responsible for post-translational modification, sorting, and transport of proteins. FAM18A's role in these processes underscores its significance in maintaining cellular homeostasis and ensuring the correct localization and function of Golgi-associated proteins.
Inhibition of FAM18A involves targeting key regulatory elements associated with Golgi dynamics. Several chemicals, such as Wortmannin, Brefeldin A, and LY294002, directly inhibit FAM18A by disrupting upstream signaling pathways, particularly those involving phosphatidylinositol 3-kinase (PI3K). Additionally, indirect inhibitors like Golgicide A, Monensin, and Bafilomycin A1 interfere with Golgi membrane trafficking and structure, impacting FAM18A function by disrupting the overall Golgi apparatus dynamics. This dual approach reflects the intricacies of Golgi-associated protein regulation, emphasizing the importance of FAM18A in maintaining Golgi homeostasis. The summarized inhibition mechanisms highlight the multifaceted nature of FAM18A's role in Golgi dynamics and protein trafficking. The targeted disruption of these processes provides insights into potential strategies for modulating FAM18A function, offering avenues for further exploration in understanding the cellular and molecular mechanisms underlying Golgi apparatus regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits phosphatidylinositol 3-kinase (PI3K), a key signaling enzyme upstream of FAM18A. By blocking PI3K activity, Wortmannin disrupts the activation of downstream pathways, impeding FAM18A-related cellular processes and leading to a reduction in FAM18A function within the Golgi apparatus membrane. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts vesicle transport between the endoplasmic reticulum (ER) and Golgi apparatus, indirectly inhibiting FAM18A by interfering with Golgi function. The perturbation of Golgi membrane dynamics and trafficking pathways hinders FAM18A's localization and function within the Golgi, contributing to an overall decrease in its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits phosphatidylinositol 3-kinase (PI3K), a crucial upstream regulator of FAM18A. By blocking PI3K activity, LY294002 disrupts the activation of downstream pathways, impeding FAM18A-related cellular processes and leading to a reduction in FAM18A function within the Golgi apparatus membrane. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A specifically targets the cis-Golgi transmembrane protein GOLPH3, indirectly inhibiting FAM18A by disrupting Golgi membrane trafficking and structure. The interference with Golgi function hampers FAM18A's localization and activity within the Golgi apparatus membrane, resulting in an overall reduction in FAM18A function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin disrupts ion homeostasis within the Golgi apparatus, indirectly inhibiting FAM18A by perturbing Golgi membrane trafficking and structure. The disturbance in Golgi function hinders FAM18A's localization and activity within the Golgi apparatus membrane, contributing to an overall decrease in FAM18A function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 inhibits vacuolar-type H+-ATPase (V-ATPase), affecting Golgi acidification and trafficking processes. Indirectly, this impedes FAM18A function within the Golgi apparatus membrane by disrupting Golgi dynamics and protein sorting, leading to an overall reduction in FAM18A activity. | ||||||
Glycocholic acid | 475-31-0 | sc-218574 sc-218574A sc-218574B sc-218574C sc-218574D sc-218574E | 100 mg 1 g 5 g 10 g 50 g 100 g | $73.00 $188.00 $680.00 $1259.00 $1675.00 $3131.00 | 4 | |
Glycocholic acid selectively inhibits the cis-Golgi transmembrane protein GOLPH3, indirectly affecting FAM18A by disrupting Golgi membrane trafficking and structure. The interference with Golgi function hampers FAM18A's localization and activity within the Golgi apparatus membrane, resulting in an overall reduction in FAM18A function. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 inhibits the guanine nucleotide exchange factor (GBF1), a key regulator of COPI vesicle formation. Indirectly, this affects FAM18A by disrupting Golgi membrane trafficking. The interference with vesicle trafficking processes hampers FAM18A's localization and activity within the Golgi apparatus membrane, leading to an overall reduction in FAM18A function. | ||||||