FAM113B Inhibitors
Chemical inhibitors of FAM113B can act through various mechanisms to disrupt its function within the mitochondrial matrix. Palmitoyl-DL-carnitine competes with the substrates or cofactors of FAM113B, leading to its inhibition. This competition can interfere with FAM113B's metabolic processes. Similarly, decylubiquinone targets the ubiquinone site within the mitochondrial electron transport chain, thereby indirectly affecting FAM113B by altering the mitochondrial membrane potential and the production of reactive oxygen species. Another inhibitor, thenoyltrifluoroacetone (TTFA), disrupts the electron flow by inhibiting mitochondrial complex II. This disruption can lead to alterations in mitochondrial function, which indirectly impacts FAM113B's activity. Additionally, 4'-Chlorodiazepam, acting on the mitochondrial translocator protein, can affect mitochondrial function and thus FAM113B by influencing the mitochondrial membrane potential.
Further, oligomycin A, targeting ATP synthase, can decrease the mitochondrial membrane potential, which in turn can influence FAM113B function. Carboxin, another complex II inhibitor, can cause a buildup of substrates and alter the mitochondrial redox state, which also indirectly inhibits FAM113B. Complex III is targeted by antimycin A, which can impact FAM113B by affecting both the mitochondrial membrane potential and ROS generation. FCCP operates as an uncoupler, dissipating the mitochondrial membrane potential and thereby affecting FAM113B's environment and function. Inhibition of complex I by rotenone can lead to changes in membrane potential and ROS levels, resulting in an indirect inhibition of FAM113B. Zinc pyrithione can inhibit FAM113B by binding to its metal cofactors, affecting metal-cofactor-dependent processes. Lastly, STO-609 inhibits CaMKK, which can indirectly affect FAM113B if it relies on CaMKK signaling pathways, and auranofin alters the cellular redox state, particularly within the mitochondria, which can affect FAM113B's functionality.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Decylubiquinone | 55486-00-5 | sc-358659 sc-358659A | 10 mg 50 mg | $69.00 $260.00 | 10 | |
Decylubiquinone acts as an inhibitor of the mitochondrial electron transport chain, specifically at the ubiquinone site. By disrupting electron transport, it can indirectly inhibit FAM113B by altering mitochondrial membrane potential and reactive oxygen species (ROS) generation, processes that FAM113B is associated with. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
Thenoyltrifluoroacetone (TTFA) is an inhibitor of mitochondrial complex II. It can inhibit FAM113B by disrupting the electron flow through the respiratory chain, potentially altering mitochondrial function and indirectly inhibiting the function of FAM113B within the mitochondria. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A inhibits mitochondrial ATP synthase, which can lead to a decrease in the mitochondrial membrane potential. This reduction in membrane potential can indirectly inhibit FAM113B by altering the mitochondrial environment that is necessary for FAM113B's function. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin is an inhibitor of mitochondrial complex II. By inhibiting complex II, Carboxin can cause a buildup of substrates and alter the mitochondrial redox state, which indirectly inhibits FAM113B by influencing the environment it functions in. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A is a specific inhibitor of mitochondrial complex III. Inhibition of complex III can affect the mitochondrial membrane potential and ROS generation, which are processes associated with FAM113B function. Through these alterations, Antimycin A can indirectly inhibit the function of FAM113B. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP (carbonyl cyanide-p-trifluoromethoxyphenylhydrazone) is a mitochondrial uncoupler. By dissipating the mitochondrial membrane potential, FCCP can indirectly inhibit FAM113B by influencing the mitochondrial environment and affecting its function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By blocking electron transport at complex I, it can lead to a change in mitochondrial membrane potential and ROS levels, which may result in the indirect inhibition of FAM113B's function in the mitochondria. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can inhibit the function of multiple proteins by binding to their metal cofactors and can indirectly inhibit FAM113B by affecting its metal-cofactor-dependent processes. | ||||||
STO-609 | 52029-86-4 | sc-507444 | 5 mg | $140.00 | ||
STO-609 is a selective inhibitor of the calcium/calmodulin-dependent protein kinase kinase (CaMKK). FAM113B, if reliant on CaMKK signaling pathways for its function, can be indirectly inhibited by STO-609 through the inhibition of CaMKK-dependent processes. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin is an inhibitor of thioredoxin reductase and can indirectly inhibit FAM113B by altering the cellular redox environment, particularly within the mitochondria where FAM113B operates, affecting its function. | ||||||