FAHD1 Inhibitors
FAHD1 inhibitors function primarily by influencing processes related to energy metabolism in which FAHD1 is directly involved. For instance, Sodium Oxamate and 2-Deoxy-D-glucose are inhibitors of LDH and glycolysis, respectively. Given that FAHD1 acts as a key enzyme in the TCAcycle, reducing the supply of substrates for the TCA cycle or the glycolytic flux can lead to the indirect inhibition of FAHD1 activity. Similarly, Dichloroacetate, a PDK inhibitor, enhances the conversion of pyruvate to acetyl-CoA. The overproduction of acetyl-CoA can overload the TCA cycle, leading to a decrease in the functional activity of FAHD1.
Furthermore, several inhibitors act by disrupting mitochondrial functions, given that the TCA cycle, in which FAHD1 is a key enzyme, provides substrates to the mitochondrial electron transport chain. Rotenone, Antimycin A, and Phenformin inhibit mitochondrial complexes I and III, while Oligomycin inhibits ATP synthase, and Azide and Cyanide inhibit cytochrome c oxidase. By inhibiting these components of the electron transport chain, these chemicals decrease TCA cycle flux, leading to the functional inhibition of FAHD1. In addition, Atractyloside, an ANT inhibitor, blocks the exchange of ADP and ATP across the mitochondrial inner membrane, which also leads to a decrease in TCA cycle flux and FAHD1 functional activity. Lastly, FCCP, an uncoupler of oxidative phosphorylation, and Malonate, a competitive inhibitor of succinate dehydrogenase, can lead to a decrease in TCA cycle flux and thus FAHD1 functional activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium oxamate | 565-73-1 | sc-215880 sc-215880B sc-215880C sc-215880D sc-215880A | 5 g 100 g 250 g 1 kg 25 g | $77.00 $469.00 $1106.00 $4111.00 $152.00 | 14 | |
Sodium Oxamate is a competitive LDH inhibitor. FAHD1 acts as a key enzyme in the TCA cycle, and the inhibition of LDH by Sodium Oxamate can reduce the supply of substrates for the TCA cycle, thus indirectly inhibiting FAHD1 activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is a glucose analog that inhibits glycolysis. Since FAHD1 is involved in the TCA cycle that is downstream of glycolysis, reducing glycolytic flux can indirectly lead to the inhibition of FAHD1's functional activity. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $61.00 $128.00 | 5 | |
Dichloroacetate is a PDK inhibitor that can stimulate PDH, enhancing the conversion of pyruvate to acetyl-CoA. Since FAHD1 is involved in the TCA cycle, the overproduction of acetyl-CoA can overload the TCA cycle, potentially leading to a decrease in FAHD1 activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is a specific inhibitor of mitochondrial complex I. Since FAHD1 is involved in the TCA cycle that provides substrates to the mitochondrial electron transport chain, the inhibition of complex I by Rotenone can lead to a decrease in TCA cycle flux and thus FAHD1 functional activity. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A is a specific inhibitor of mitochondrial complex III. Given the role of FAHD1 in the TCA cycle that provides substrates to the mitochondrial electron transport chain, the inhibition of complex III by Antimycin A can lead to a decrease in TCA cycle flux and thus FAHD1 functional activity. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin is a specific inhibitor of mitochondrial ATP synthase. Given the role of FAHD1 in the TCA cycle that provides substrates to the mitochondrial electron transport chain, the inhibition of ATP synthase by Oligomycin can lead to a decrease in TCA cycle flux and thus FAHD1 functional activity. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Azide is a cytochrome c oxidase inhibitor. Given that FAHD1 is involved in the TCA cycle, which provides substrates to the mitochondrial electron transport chain, the inhibition of cytochrome c oxidase by Azide can lead to a decrease in TCA cycle flux and thus FAHD1 functional activity. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Phenformin is a biguanide that can inhibit complex I and stimulate AMPK, which can decrease the TCA cycle flux. Since FAHD1 is involved in the TCA cycle, the inhibition of complex I and stimulation of AMPK by Phenformin can lead to a decrease in FAHD1 functional activity. | ||||||
α-Cyano-4-hydroxycinnamic acid | 28166-41-8 | sc-254923 | 2 g | $43.00 | 2 | |
Cyanide is a potent inhibitor of cytochrome c oxidase in the mitochondrial electron transport chain. Given that FAHD1 is involved in the TCA cycle, which provides substrates to the mitochondrial electron transport chain, the inhibition of cytochrome c oxidase by Cyanide can lead to a decrease in TCA cycle flux and thus FAHD1 functional activity. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP is an uncoupler of oxidative phosphorylation in mitochondria. As FAHD1 is involved in the TCA cycle that provides substrates to the mitochondrial electron transport chain, the uncoupling of oxidative phosphorylation by FCCP can lead to a decrease in TCA cycle flux and thus FAHD1 functional activity. | ||||||