EXT2 Inhibitors
EXT2 inhibitors belong to a distinctive chemical class characterized by their ability to selectively target and modulate the activity of the EXTL2 enzyme. EXTL2, or exostosin-like glycosyltransferase 2, is a member of the exostosin family of glycosyltransferases that play a crucial role in the biosynthesis of heparan sulfate (HS), a complex and highly sulfated polysaccharide found on the cell surface and within the extracellular matrix. The inhibition of EXTL2 represents a strategic approach in influencing HS biosynthesis, as this enzyme is implicated in the polymerization step, contributing to the elongation of heparan sulfate chains. By specifically targeting EXTL2, inhibitors of this class intervene in the finely tuned process of HS chain elongation, exerting a regulatory effect on the overall structure and composition of heparan sulfate.
EXT2 inhibitors are designed to interact with the catalytic site of EXTL2, disrupting its enzymatic activity and thereby modulating the length and sulfation pattern of heparan sulfate chains. The rationale behind targeting EXTL2 lies in the pivotal role of heparan sulfate in various cellular processes, including cell signaling, adhesion, and migration. As such, the development of EXT2 inhibitors opens up avenues for exploring the intricate functions of heparan sulfate in health and disease.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin inhibits various growth factors and can disrupt the signaling pathways that EXT2's products, heparan sulfate proteoglycans, are involved in. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese is a cofactor for various enzymes and in excess can perturb enzyme function, potentially affecting those that interact with EXT2. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavonoids like Flavopiridol have been reported to inhibit glycosaminoglycan synthesis, which could indirectly affect EXT2 functional pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can inhibit glycosaminoglycan synthesis and could interfere with the production of substrates necessary for EXT2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that can inhibit tyrosine kinases and could modulate signaling pathways relevant to EXT2's function. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Though biological, its inclusion is for context as it can degrade heparan sulfate, thus altering the EXT2 substrate pool indirectly. | ||||||
4-Methylumbelliferyl-β-D-xylopyranoside | 6734-33-4 | sc-220964 sc-220964A | 25 mg 100 mg | $71.00 $233.00 | ||
Beta-D-xyloside can initiate glycosaminoglycan chains independent of proteoglycans, potentially altering EXT2's normal function. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is a nucleoside analog that can disrupt metabolic pathways, potentially influencing EXT2's glycosylation activity. | ||||||