epsin2 Activators
Epsin2 Activators are a collection of chemical compounds that indirectly facilitate the heightened functional activity of epsin2 predominantly through modulating endocytosis and intracellular trafficking mechanisms. The presence of compounds like Phosphatidylinositol-4,5-bisphosphate and Amphiphysin enriches plasma membrane localization and stabilizes membrane curvature, thus optimizing the recruitment and function of epsin2 in clathrin-mediated endocytosis. Dynasore, by inhibiting dynamin GTPase activity, inadvertently increases epsin2's concentration at endocytic sites, while Echistatin redirects epsin2's activity by encouraging integrin endocytosis. Pitstop 2, through impeding clathrin terminal domain interactions, can redistribute epsin2 to alternate endocytic pathways, enhancing its functional diversity. Additionally, compounds like Monodansylcadaverine and Nystatin indirectly augment epsin2's role by instigating a compensatory uptake of cellular components, while Jasplakinolide and Cytochalasin D modulate actin dynamics, thus influencing epsin2's role in actin-dependent endocytic processes.
Further, the action of Wiskostatin and Methyl-β-cyclodextrin indirectly promotes the activity of epsin2 by disrupting N-WASP-mediated actin assembly and depleting plasma membrane cholesterol, respectively, which can lead to upregulated endocytosis as a cellular response mechanism. Similarly, Latrunculin A, by disorganizing actin filaments, can trigger an increased clathrin-mediated endocytic activity, indirectly enhancing the role of epsin2. The coordinated effects of these chemical activators converge on the intricate network of cellular endocytosis and trafficking, where epsin2 is a critical player, leading to its enhanced functional activity without directly influencing its expression levels or employing direct activation pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA is an omega-3 fatty acid that can be incorporated into membrane phospholipids. When it is metabolized, it can alter the composition and distribution of phospholipids like PIP2, thereby indirectly enhancing the membrane deformation activity of epsin 2. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that can influence the recruitment of proteins to membrane sites. Through its effect on membrane lipid composition, S1P indirectly promotes the activity of epsin 2 by affecting its localization and function in endocytosis. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a polyunsaturated fatty acid involved in signaling and membrane fluidity. It can be metabolized into various eicosanoids which can affect the distribution of phosphoinositides, indirectly enhancing the endocytic activity of epsin 2. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is an essential component of cell membranes, affecting fluidity and curvature. By modulating the physical properties of membranes, cholesterol can indirectly influence the activity of epsin 2 in processes like clathrin-mediated endocytosis. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a monounsaturated fatty acid that integrates into cellular membranes, affecting their properties. By changing the membrane composition, oleic acid can indirectly enhance the endocytosis-related functions of epsin 2. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA is a signaling lipid that can alter membrane curvature and dynamics. By influencing the lipid composition of membranes, LPA can indirectly support the membrane-deforming activity of epsin 2 during endocytosis. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide is a sphingolipid that can induce membrane curvature and is involved in signaling pathways. Its effects on membrane properties can indirectly promote the localization and function of epsin 2 in vesicle formation. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
DHA is an omega-3 fatty acid that, when incorporated into membrane phospholipids, can influence the distribution of signaling lipids such as PIP2. This can indirectly augment the activity of epsin 2 in its role in endocytosis. | ||||||
Sphingomyelin | 85187-10-6 | sc-201381 sc-201381A | 100 mg 500 mg | $180.00 $560.00 | 3 | |
Sphingomyelin is a type of sphingolipid found in cell membranes that impacts the biophysical properties of the lipid bilayer. Changes in membrane composition involving sphingomyelin can indirectly enhance the activity of epsin 2 in endocytic processes. | ||||||