Date published: 2025-12-24

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EML5 Inhibitors

EML5 Inhibitors comprise a class of chemical compounds designed to interact with and regulate the activity of the EML5 protein, a member of the EML (EMAP-like) family of proteins. EML proteins play diverse roles in cellular processes, including microtubule organization and dynamics, which are essential for intracellular transport, cell division, and other key functions. Inhibitors targeting EML5 are developed to interfere with or modulate its function, thus affecting microtubule dynamics and other cellular activities associated with this protein. The mechanism of action for EML5 inhibitors typically involves binding to specific regions or domains within the EML5 protein. This interaction may disrupt its ability to associate with microtubules, affecting their organization and stability. By altering the dynamics of microtubules and their interactions with motor proteins and other cellular components, these inhibitors offer valuable insights into the intricate processes of intracellular transport, cell division, and cell motility. Researchers employ EML5 inhibitors as crucial tools to elucidate the roles played by EML5 in various cellular functions and the underlying mechanisms governing microtubule dynamics. Through such investigations, scientists gain a deeper understanding of fundamental cellular processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$198.00
$650.00
16
(1)

A-83-01 is a selective inhibitor of TGF-beta type I receptor (ALK5). While it primarily targets ALK5, it may indirectly affect EML5 through its role in TGF-beta signaling pathways.

Ro 31-8220

138489-18-6sc-200619
sc-200619A
1 mg
5 mg
$90.00
$240.00
17
(1)

Ro 31-8220 is a kinase inhibitor targeting various protein kinases, including protein kinase C (PKC). PKC can regulate microtubule dynamics, and EML5's function in microtubule organization may be influenced by Ro 31-8220's impact on PKC.

MLN8237

1028486-01-2sc-394162
5 mg
$220.00
(0)

MLN8237, also known as Alisertib, is an Aurora A kinase inhibitor. EML5 is linked to the regulation of centrosome function and microtubule organization, and Aurora A kinase plays a role in these processes, so inhibiting it with MLN8237 may indirectly affect EML5.

MLN 8054

869363-13-3sc-484828
5 mg
$398.00
(0)

MLN8054 is an inhibitor of Aurora A kinase, similar to Alisertib (MLN8237). By targeting Aurora A kinase, it may indirectly affect EML5's role in centrosome regulation and microtubule organization.

CGP-60474

164658-13-3sc-507525
5 mg
$165.00
(0)

CGP60474 is an inhibitor of multiple kinases, including CDKs, which are known to play a role in microtubule dynamics. Inhibition of CDKs with CGP60474 may indirectly affect EML5 functions related to the microtubules.