EG624219 Inhibitors
The chemical class defined as Angptl8 inhibitors is largely characterized by compounds that intervene in lipid metabolism and triglyceride homeostasis. Agents such as Atorvastatin, Fenofibrate, and Gemfibrozil act upon key enzymes or nuclear receptors like HMG-CoA reductase and PPARα, thereby modulating lipid metabolic pathways that are known to be regulated by Angptl8. Similarly, PPARγ agonists like Rosiglitazone and Pioglitazone can influence adipocyte differentiation and fat cell maturation, processes where Angptl8 is a known participant.
On the other hand, chemicals like Cilostazol and Orlistat, which are not directly related to lipid metabolism, also serve to modify Angptl8's biological functions. Cilostazol inhibits PDE3, which has a downstream effect on triglyceride levels. Orlistat directly inhibits pancreatic lipase, affecting triglyceride breakdown and thereby Angptl8's role. These compounds highlight the multifaceted approach to inhibiting Angptl8 and its complex involvement in lipid metabolism and homeostasis. Note that these compounds can either directly or indirectly affect the biological pathways where Angptl8 is involved, thereby modulating its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Atorvastatin inhibits HMG-CoA reductase, a key enzyme in lipid metabolism. By affecting lipid levels, it can indirectly regulate Angptl8's function in lipid metabolic processes. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate activates PPARα, which is involved in fatty acid oxidation. This can indirectly reduce the actions of Angptl8 in lipid and triglyceride homeostasis. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Gemfibrozil acts on PPARα, leading to a decrease in triglycerides, which can indirectly modulate Angptl8’s role in triglyceride homeostasis. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Activates PPARγ, and thereby can influence fat cell differentiation, a process Angptl8 is involved in. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol inhibits phosphodiesterase 3 (PDE3) and can reduce triglyceride levels, thus affecting Angptl8's role in triglyceride homeostasis. | ||||||
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $52.00 | 7 | |
By inhibiting pancreatic lipase, orlistat prevents triglyceride breakdown, thus indirectly modulating Angptl8's role in lipid metabolic processes. | ||||||
Probucol | 23288-49-5 | sc-203666 sc-203666A | 100 mg 1 g | $79.00 $166.00 | 5 | |
Antioxidant that can reduce LDL-C, indirectly impacting Angptl8's role in lipoprotein metabolic process. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Increases HDL-C and reduces triglycerides. By affecting lipid profiles, it indirectly regulates Angptl8. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Known for its hepatoprotective effects, silybin can regulate lipid metabolic pathways, thereby affecting Angptl8's roles in these processes. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
Involved in fatty acid oxidation, L-carnitine can indirectly influence Angptl8 by modulating lipid metabolic processes. | ||||||