EF-Ts Inhibitors
EF-Ts inhibitors primarily work by binding to the bacterial ribosome, either to its 30S or 50S subunit, and interfering with various stages of the protein synthesis process, including initiation, elongation, and termination. By doing so, they prevent the proper functioning of the elongation factors, among which EF-Ts is a key player.
EF-Ts inhibitors interfere with the association of aminoacyl-tRNA with the ribosome, which is a step where EF-Ts indirectly plays a role by recycling EF-Tu for subsequent rounds of elongation. They also work by blocking the peptidyl transferase reaction and initiation complex formation, respectively, both of which are essential for continuous protein synthesis and indirectly involve EF-Ts function. These inhibtors also target the translocation step and EF-G cycling, which, while not directly impinging on EF-Ts, would still result in a downstream impact on its function due to the halt in protein synthesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Binds to the 30S subunit of bacterial ribosomes, preventing attachment of aminoacyl-tRNA to the A site, indirectly affecting EF-Ts function by inhibiting elongation. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Binds to the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase activity, which can alter EF-Ts activity indirectly by blocking the peptide elongation. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Mimics the structure of aminoacyl-tRNA and incorporates into the growing peptide chain, causing premature chain termination and indirectly impacting EF-Ts function. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Binds to the 50S ribosomal subunit and inhibits translocation, which would indirectly affect EF-Ts activity by halting protein synthesis. | ||||||
Fusidic acid | 6990-06-3 | sc-215065 | 1 g | $292.00 | ||
Prevents the turnover of elongation factor G (EF-G) from the ribosome, indirectly affecting EF-Ts function by stalling protein synthesis. | ||||||
Gentamicin Sulfate, 500X Solution | 1405-41-0 | sc-29066A sc-29066 | 10 ml 20 ml | $48.00 $85.00 | 12 | |
Bind to the 30S ribosomal subunit, causing misreading of mRNA and inhibiting translocation, which can indirectly affect EF-Ts. | ||||||